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Diabetes, oxidative stress and cardiovascular risk


Butkowski, EG and Brix, LM and Kiat, H and Al-Aubaidy, HA and Jelinek, HF, Diabetes, oxidative stress and cardiovascular risk, Basic Research Journal of Medicine and Clinical Sciences, 5, (1) pp. 17-23. ISSN 2315-6864 (2016) [Refereed Article]


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Copyright 2015 Basic Research Journal

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Type 2 Diabetes Mellitus (T2DM) and associated cardiovascular disease (CVD) is approaching global epidemic proportions with no signs of abatement. This current study examined correlations between inflammation and oxidative stress in (T2DM) and the Framingham CVD risk score. A cross sectional cohort of patients enrolling in the Diabetic Complications Research Initiative at Charles Sturt University was examined for diabetes status and divided into control, prediabetic, and a T2DM groups. The cohort was also divided with respect to Framingham CVD risk categories of low, moderate and high risk. Fasting lipid levels, blood glucose, glycated haemoglobin (HbA1c), interleukin 6, (IL-6), glutathione (GSH) and glutathione disulfide (GSSG) were measured. Body Mass Index (BMI), blood pressure and estimated glomerular filtration rate (eGFR) were included. Significant correlations in diabetes status and CVD risk with GSH and IL-6 were observed. This study further supports previous data that inflammatory processes and oxidative stress are implicated in T2DM and CVD risk.

Item Details

Item Type:Refereed Article
Keywords:type 2 diabetes mellitus, prediabetes, cardiovascular disease, oxidative stress, risk factors, body mass index, glutathione, glutathione disulfide, interleukin-6
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biochemistry and metabolomics
Research Field:Medical biochemistry - carbohydrates
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Al-Aubaidy, HA (Dr Hayder Al-Aubaidy)
ID Code:108314
Year Published:2016
Deposited By:Medicine
Deposited On:2016-04-18
Last Modified:2018-03-07
Downloads:122 View Download Statistics

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