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Transthyretin distribution in the developing choroid plexus of the South American opossum (Monodelphis domestica)


Li, ZS and Dziegielewska, KM and Saunders, NR, Transthyretin distribution in the developing choroid plexus of the South American opossum (Monodelphis domestica), Cell and Tissue Research, 287, (3) pp. 621-624. ISSN 0302-766X (1997) [Refereed Article]

DOI: doi:10.1007/s004410050785


The distributions of transthyretin and albumin in the choroid plexus during brain development have been compared. The South American opossum was chosen because the young are born around the time of choroid plexus formation. Previous work showed that in the adult opossum, transthyretin is expressed in the choroid plexus cells. However, systematic studies of transthyretin in the choroid plexus during development have not been carried out before. Transthyretin was present in 90-95% of the choroidal cells from birth to adulthood. In most cells, transthyretin immunoreactivity was concentrated in the apical region of the cytoplasm. Double labelling of choroid plexus sections with antibodies to albumin and transthyretin showed that 1-2% of cells were positive for both proteins. These findings suggest that from the very earliest stage of choroid plexus formation most epithelial cells both synthesize and contain transthyretin, and a few of these transthyretin-synthesizing cells also contain albumin that is probably being transferred from blood to the cerebrospinal fluid.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the environmental sciences
UTAS Author:Dziegielewska, KM (Dr Kate Dziegielewska)
UTAS Author:Saunders, NR (Professor Norman Saunders)
ID Code:10831
Year Published:1997
Web of Science® Times Cited:6
Deposited By:Anatomy and Physiology
Deposited On:1997-08-01
Last Modified:2011-08-11

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