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Parental history of diabetes in an insulin-treated diabetes registry


Riley, MD and Blizzard, CL and McCarty, DJ and Senator, GB and Dwyer, T and Zimmet, P, Parental history of diabetes in an insulin-treated diabetes registry, Diabetic Medicine, 14, (1) pp. 35-41. ISSN 0742-3071 (1997) [Refereed Article]

DOI: doi:10.1002/(SICI)1096-9136(199701)14:1<35::AID-DIA296>3.3.CO;2-9


To confirm observations of an excess maternal transmission of Type 2 (non-insulin dependent) diabetes mellitus in a setting which minimizes potential biases and confounders, we explored the patterns of maternal and paternal diabetes in a cohort (n=1775) of subjects with insulin-treated diabetes mellitus (ITDM) in Tasmania, Australia. In order to identify individuals with Type 1 diabetes or insulin-treated Type 2 diabetes, cases were classified into groups based on their age at diagnosis and subsequent time to commencement of insulin. Individuals initially diagnosed younger than age 30 (predominantly Type 1 diabetes cases) reported a similar percentage of mothers and fathers with diabetes, but individuals diagnosed at age 30 or older (predominantly insulin-treated Type 2 diabetes) reported a maternal excess of diabetes. Having an elevated body mass index was associated with a higher frequency of maternal diabetes, but not of paternal diabetes. Because both childhood-onset Type 1 diabetes and adult-onset insulin-treated Type 2 diabetes cases were subject to the same potential study biases, these results offer support for an excess maternal role in Type 2 diabetes transmission.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Riley, MD (Mr Malcolm Riley)
UTAS Author:Blizzard, CL (Professor Leigh Blizzard)
UTAS Author:Dwyer, T (Professor Terry Dwyer)
ID Code:10819
Year Published:1997
Web of Science® Times Cited:20
Deposited By:Menzies Centre
Deposited On:1997-08-01
Last Modified:2011-08-11

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