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How does transcranial magnetic stimulation influence glial cells in the central nervous system?


Cullen, CL and Young, KM, How does transcranial magnetic stimulation influence glial cells in the central nervous system?, Frontiers in Neural Circuits, 10 Article 26. ISSN 1662-5110 (2016) [Refereed Article]


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Copyright 2016 the authors Licenced under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.3389/fncir.2016.00026


Transcranial magnetic stimulation (TMS) is widely used in the clinic, and while it has a direct effect on neuronal excitability, the beneficial effects experienced by patients are likely to include the indirect activation of other cell types. Research conducted over the past two decades has made it increasingly clear that a population of non-neuronal cells, collectively known as glia, respond to and facilitate neuronal signaling. Each glial cell type has the ability to respond to electrical activity directly or indirectly, making them likely cellular effectors of TMS. TMS has been shown to enhance adult neural stem and progenitor cell (NSPC) proliferation, but the effect on cell survival and differentiation is less certain. Furthermore there is limited information regarding the response of astrocytes and microglia to TMS, and a complete paucity of data relating to the response of oligodendrocyte-lineage cells to this treatment. However, due to the critical and yet multifaceted role of glial cells in the central nervous system (CNS), the influence that TMS has on glial cells is certainly an area that warrants careful examination.

Item Details

Item Type:Refereed Article
Keywords:oligodendrocyte, astrocyte, neural stem cell, microglia, glia, transcranial magnetic stimulation, neural activity, magnetic
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Cullen, CL (Dr Carlie Cullen)
UTAS Author:Young, KM (Professor Kaylene Young)
ID Code:108111
Year Published:2016
Funding Support:National Health and Medical Research Council (1045240)
Web of Science® Times Cited:61
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-04-06
Last Modified:2022-08-23
Downloads:210 View Download Statistics

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