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Associations between Maternal Antioxidant Intakes in Pregnancy and Infant Allergic Outcomes

Citation

West, CE and Dunstan, J and McCarthy, S and Metcalfe, J and D'Vaz, N and Meldrum, S and Oddy, WH and Tulic, MK and Prescott, SL, Associations between Maternal Antioxidant Intakes in Pregnancy and Infant Allergic Outcomes, Nutrients, 4, (11) pp. 1747-1758. ISSN 2072-6643 (2012) [Refereed Article]

DOI: doi:10.3390/nu4111747

Abstract

Antioxidant intakes in pregnancy may influence fetal immune programming and the risk of allergic disease. We investigated associations between maternal intakes of β-carotene, vitamin C, vitamin E, copper and zinc, and infant allergic outcomes. Antioxidant intakes of pregnant women (n = 420) assessed prospectively by a food frequency questionnaire, were examined in relation to allergic outcomes at 1 year of age (n = 300). The main relationships with allergic outcomes were seen with dietary vitamin C and copper. Specifically, higher maternal dietary vitamin C intake was associated with a reduced risk of any diagnosed infant allergic disease and wheeze. After adjustment for potential confounders the relationship with wheeze remained statistically significant. There was also an inverse linear relationship between vitamin C and food allergy. Higher dietary copper intake was associated with reduced risk of eczema, wheeze and any allergic disease. The relationship with wheeze and any allergic disease remained statistically significant in multivariate analysis, and there was also an inverse linear relationship between copper and food allergy. However, these relationships were only seen for nutrients present in food. There were no relationships between β-carotene, vitamin E or zinc and any allergic outcomes. In summary, this study suggests that maternal diet of fresh foods rich in vitamin C is associated with reduced risk of infant wheeze, and that copper intake is associated with reduced risk of several allergic outcomes.

Item Details

Item Type:Refereed Article
Keywords:allergy, allergic disease, antioxidant, childhood, copper, diet, dietary intake, eczema, pregnancy, vitamin C
Research Division:Medical and Health Sciences
Research Group:Nutrition and Dietetics
Research Field:Clinical and Sports Nutrition
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Nutrition
Author:Oddy, WH (Professor Wendy Oddy)
ID Code:108023
Year Published:2012
Web of Science® Times Cited:27
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-04-04
Last Modified:2017-11-06
Downloads:0

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