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Promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus is associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy
Citation
Kaidonis, G and Craig, JE and Gillies, MC and Abhary, S and Essex, RW and Chang, JH and Pal, B and Pefkianaki, M and Daniell, M and Lake, S and Petrovsky, N and Burdon, KP, Promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus is associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy, Diabetes and Vascular Disease Research, 13, (2) pp. 164-167. ISSN 1479-1641 (2016) [Refereed Article]
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Copyright Statement
© The Author(s) 2016
DOI: doi:10.1177/1479164115616902
Abstract
METHODS: A total of 334 type 1 diabetes and 999 type 2 diabetes participants with sight-threatening diabetic retinopathy, and 260 type 1 diabetes and 901 type 2 diabetes participants with no diabetic retinopathy or minimal non-proliferative diabetic retinopathy, were genotyped for two single nucleotide polymorphisms (rs1800629 and rs361525).
RESULTS: The A allele of rs1800629 was associated with type 1 diabetes (p < 0.001; odds ratio = 0.62). After adjustment for age, sex, diabetes duration, HbA1c, hypertension and nephropathy, no significant association was found between rs1800629 or rs361525 and sight-threatening diabetic retinopathy.
CONCLUSION: An association between the A allele of rs1800629 and type of diabetes was found. No association was found between two promoter variants of TNF and LTA, and diabetic retinopathy in a large cohort of Caucasian patients with type 1 diabetes and type 2 diabetes.
Item Details
Item Type: | Refereed Article |
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Keywords: | Diabetic retinopathy, genetics, tumour necrosis factor, lymphotoxin-alpha, diabetes |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Ophthalmology and optometry |
Research Field: | Ophthalmology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Burdon, KP (Professor Kathryn Burdon) |
ID Code: | 107924 |
Year Published: | 2016 |
Web of Science® Times Cited: | 4 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2016-03-31 |
Last Modified: | 2018-12-07 |
Downloads: | 12 View Download Statistics |
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