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Subcutaneous tocilizumab for the treatment of rheumatoid arthritis

Citation

Mitchell, E and Jones, G, Subcutaneous tocilizumab for the treatment of rheumatoid arthritis, Expert Review of Clinical Immunology, 12, (2) pp. 103-114. ISSN 1744-666X (2016) [Refereed Article]

Copyright Statement

2016 Taylor & Francis

DOI: doi:10.1586/1744666X.2016.1127159

Abstract

Rheumatoid arthritis (RA) is characterized by inflammatory synovitis and is mediated by several cytokines; this includes interleukin-6, whose receptor has been successfully targeted by the humanized monoclonal antibody tocilizumab. Intravenous tocilizumab (TCZ-IV) is registered for use in RA (alone or as combination therapy), systemic juvenile idiopathic arthritis and Castleman disease. Subcutaneous tocilizumab (TCZ-SC) is a desirable alternative to existing subcutaneous biological disease modifying antirheumatic drugs (bDMARDs) targeting tumor necrosis factor. TCZ-SC efficacy has been evaluated in three randomized controlled trials. BREVACTA demonstrated superiority to placebo, and both MUSASHI and SUMMACTA demonstrated non-inferiority to TCZ-IV. TCZ-SC has a similar safety profile to TCZ-IV apart from increased rates of injection site reactions and development of anti-TCZ antibodies (the latter of uncertain clinical significance). TCZ-SC 162 mg fortnightly is equivalent to TCZ-IV 4 mg/kg fourth weekly; TCZ-SC 162 mg weekly is equivalent to TCZ-IV 8 mg/kg fourth weekly. TCZ-SC is a suitable bDMARD for RA, particularly when monotherapy is preferred.

Item Details

Item Type:Refereed Article
Keywords:IL-6, rheumatoid, tocilizumab, subcutaneous, trial
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Jones, G (Professor Graeme Jones)
ID Code:107922
Year Published:2016
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-03-31
Last Modified:2017-11-01
Downloads:1 View Download Statistics

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