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Pre-pregnancy maternal overweight and obesity increase the risk for affective disorders in offspring


Robinson, M and Zubrick, SR and Pennell, CE and Van Lieshout, RJ and Jacoby, P and Beilin, LJ and Mori, TA and Stanley, FJ and Newnham, JP and Oddy, WH, Pre-pregnancy maternal overweight and obesity increase the risk for affective disorders in offspring, Journal of Developmental Origins of Health and Disease, 4, (1) pp. 42-48. ISSN 2040-1744 (2013) [Refereed Article]

DOI: doi:10.1017/S2040174412000578


Maternal pre-pregnancy obesity has been linked with an increased risk for negative emotionality and inattentiveness in offspring in early childhood. The aim of this study was to examine the association between maternal pre-pregnancy body mass index (BMI) and the development of affective problems (dysthymic disorder, major depressive disorder) throughout childhood and adolescence. In the Western Australian Pregnancy Cohort (Raine) Study, 2900 women provided data on their pre-pregnancy weight, and height measurements were taken at 18 weeks of gestation. BMI was calculated and categorized using standardized methods. Live-born children (n = 2868) were followed up at ages 5, 8, 10, 14 and 17 years using the Diagnostic and Statistical Manual of Mental Disorders-oriented scales of the Child Behavior Checklist (CBCL/4-18). Longitudinal models were applied to assess the relationships between maternal pre-pregnancy BMI and affective problems from age 5 through 17. There was a higher risk of affective problems between the ages of 5 and 17 years among children of women who were overweight and obese compared with the offspring of women in the healthy pre-pregnancy weight range (BMI 18.5-24.99) after adjustment for confounders, including paternal BMI. Maternal pre-pregnancy overweight and obesity may be implicated in the development of affective problems, including depression, in their offspring later in life.

Item Details

Item Type:Refereed Article
Keywords:depression, mood disorders, obesity, overweight, pre-pregnancy maternal weight
Research Division:Medical and Health Sciences
Research Group:Nutrition and Dietetics
Research Field:Clinical and Sports Nutrition
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Nutrition
Author:Oddy, WH (Professor Wendy Oddy)
ID Code:107906
Year Published:2013
Web of Science® Times Cited:14
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-03-31
Last Modified:2017-11-06

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