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Interplay between transcription factors and the epigenome: insight from the role of RUNX1 in leukemia


Brettingham-Moore, KH and Taberlay, PC and Holloway, AF, Interplay between transcription factors and the epigenome: insight from the role of RUNX1 in leukemia, Frontiers in Immunology, 6 Article 499. ISSN 1664-3224 (2015) [Refereed Article]


Copyright Statement

2015 Brettingham-Moore, Taberlay and Holloway. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.3389/fimmu.2015.00499


The genome has the ability to respond in a precise and co-ordinated manner to cellular signals. It achieves this through the concerted actions of transcription factors and the chromatin platform, which are targets of the signaling pathways. Our understanding of the molecular mechanisms through which transcription factors and the chromatin landscape each control gene activity has expanded dramatically over recent years, and attention has now turned to understanding the complex, multifaceted interplay between these regulatory layers in normal and disease states. It has become apparent that transcription factors as well as the components and modifiers of the epigenetic machinery are frequent targets of genomic alterations in cancer cells. Through the study of these factors, we can gain unique insight into the dynamic interplay between transcription factors and the epigenome, and how their dysregulation leads to aberrant gene expression programs in cancer. Here, we will highlight how these factors normally co-operate to establish and maintain the transcriptional and epigenetic landscape of cells, and how this is reprogramed in cancer, focusing on the RUNX1 transcription factor and oncogenic derivative RUNX1-ETO in leukemia as paradigms of transcriptional and epigenetic reprograming.

Item Details

Item Type:Refereed Article
Keywords:epigenome, chromatin, cancer, epigenetic mechanisms, RUNX1, cancer epigenetics
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Epigenetics (incl. genome methylation and epigenomics)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Brettingham-Moore, KH (Dr Kate Brettingham-Moore)
UTAS Author:Taberlay, PC (Associate Professor Phillippa Taberlay)
UTAS Author:Holloway, AF (Professor Adele Holloway)
ID Code:107823
Year Published:2015
Web of Science® Times Cited:21
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-03-25
Last Modified:2017-11-02
Downloads:177 View Download Statistics

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