de Graaff, B and Neil, A and Sanderson, K and Yee, KC and Palmer, AJ, Quality of life utility values for hereditary haemochromatosis in Australia, Health and Quality of Life Outcomes, 14, (1) Article 31. ISSN 1477-7525 (2016) [Refereed Article]
Copyright 2016 de Graaff et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
METHODS: Volunteers with HH were recruited to complete a web-based survey. Utility was assessed using the Assessment of Quality of Life 4D (AQOL-4D) instrument. Severity of HH was graded into four categories. Multivariable regression analysis was performed to identify parameters associated with HSUV.
RESULTS: Between November 2013 and November 2014, 221 people completed the survey. Increasing severity of HH was negatively associated with utility. Mean (standard deviation) utilities were 0.76 (0.21), 0.81 (0.18), 0.60 (0.27), and 0.50 (0.27) for categories 1-4 HH respectively. Lower mean utility was found for symptomatic participants (categories 3 and 4) compared with asymptomatic participants (0.583 v. 0.796). Self-reported HH-related symptoms were negatively associated with HSUV (r = -0.685).
CONCLUSIONS: Symptomatic stages of HH and presence of multiple self-reported symptoms were associated with decreasing utility. Previous economic analyses have used higher utilities which likely resulted in underestimates of the cost effectiveness of HH interventions. The utilities reported in this paper are the most robust available, and will contribute to improving the validity of future economic models for HH.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Blood Disorders|
|Author:||de Graaff, B (Ms Barbara de Graaff)|
|Author:||Neil, A (Dr Amanda Neil)|
|Author:||Sanderson, K (Associate Professor Kristy Sanderson)|
|Author:||Yee, KC (Dr Kwang Yee)|
|Author:||Palmer, AJ (Professor Andrew Palmer)|
|Web of Science® Times Cited:||2|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||9 View Download Statistics|
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