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The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells

Citation

Gatto, D and Wood, K and Caminschi, I and Murphy-Durland, D and Schofield, P and Christ, D and Karupiah, G and Brink, R, The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells, Nature Immunology, 14, (5) pp. 446-453. ISSN 1529-2908 (2013) [Refereed Article]

Copyright Statement

2013 Nature America

DOI: doi:10.1038/ni.2555

Abstract

Spleen-resident dendritic cell (DC) populations occupy sentinel positions for the capture and presentation of blood-borne antigens. Here we found a difference in expression of the chemotactic receptor EBI2 (GPR183) on splenic DC subsets and that EBI2 regulated the positioning and homeostasis of DCs in the spleen. EBI2 and its main ligand, 7a,25-OHC, were required for the generation of the splenic CD4+ DC subset and the localization of DCs in bridging channels. Absence of EBI2 from DCs resulted in defects in both the activation of CD4+ T cells and the induction of antibody responses. Regulated expression of EBI2 on DC populations is therefore critical for the generation and correct positioning of splenic DCs and the initiation of immune responses.

Item Details

Item Type:Refereed Article
Keywords:Immune homeostatis, dendritic cells, antibody production, chemotaxis
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Immune System and Allergy
Author:Karupiah, G (Associate Professor Guna Karupiah)
ID Code:107807
Year Published:2013
Web of Science® Times Cited:58
Deposited By:Medicine (Discipline)
Deposited On:2016-03-24
Last Modified:2017-11-07
Downloads:0

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