University of Tasmania
Browse

File(s) under permanent embargo

Inflammation and immune regulation as potential drug targets in antidepressant treatment

journal contribution
posted on 2023-05-18, 18:07 authored by Schmidt, FM, Kenneth KirkbyKenneth Kirkby, Lichtblau, N
Growing evidence supports a mutual relationship between inflammation and major depression. A variety of mechanisms are outlined, indicating how inflammation may be involved in the pathogenesis, course and treatment of major depression. In particular, this review addresses 1) inflammatory cytokines as markers of depression and potential predictors of treatment response, 2) findings that cytokines interact with antidepressants and non-pharmacological antidepressive therapies, such as electroconvulsive therapy, deep brain stimulation and physical activity, 3) the influence of cytokines on the cytochrome (CYP) p450-system and drug efflux transporters, and 4) how cascades of inflammation might serve as antidepressant drug targets. A number of clinical trials have focused on agents with immunmodulatory properties in the treatment of depression, of which this reviews covers nonsteroidal anti-inflammatory drugs (NSAIDs), cytokine inhibitors, ketamine, polyunsaturated fatty acids, statins and curcumin. A perspective is also provided on possible future immune targets for antidepressant therapy, such as toll-like receptor-inhibitors, glycogen synthase kinase-3 inhibitors, oleanolic acid analogs and minocycline. Concluding from the available data, markers of inflammation may become relevant factors for more personalised planning and prediction of response of antidepressant treatment strategies. Agents with anti-inflammatory properties have the potential to serve as clinically relevant antidepressants. Further studies are required to better define and identify subgroups of patients responsive to inflammatory agents as well as to define optimal time points for treatment onset and duration.

History

Publication title

Current Neuropharmacology

Volume

14

Issue

7

Pagination

674-87

ISSN

1570-159X

Department/School

Tasmanian School of Medicine

Publisher

Bentham Science Publishers

Place of publication

United Arab Emirates

Rights statement

Copyright 2016 Bentham Science Publishers

Repository Status

  • Restricted

Socio-economic Objectives

Mental health

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC