eCite Digital Repository
Do microglia default on network maintenance in Alzheimer's disease?
Citation
Southam, KA and Vincent, AJ and Small, DH, Do microglia default on network maintenance in Alzheimer's disease?, Journal of Alzheimer's Disease, 51, (3) pp. 657-669. ISSN 1387-2877 (2016) [Refereed Article]
![]() | PDF 229Kb |
Copyright Statement
Copyright 2016 – IOS Press and the authors. All rights reserved This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License.
Abstract
Although the cause of Alzheimer's disease (AD) remains unknown, a number of new findings suggest that the immune system may play a critical role in the early stages of the disease. Genome-wide association studies have identified a wide array of risk-associated genes for AD, many of which are associated with abnormal functioning of immune cells. Microglia are the brain's immune cells. They play an important role in maintaining the brain's extracellular environment, including clearance of aggregated proteins such as amyloid-β (Aβ). Recent studies suggest that microglia play a more active role in the brain than initially considered. Specifically, microglia provide trophic support to neurons and also regulate synapses. Microglial regulation of neuronal activity may have important consequences for AD. In this article we review the function of microglia in AD and examine the possible relationship between microglial dysfunction and network abnormalities, which occur very early in disease pathogenesis.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | microglia, network abnormalities, neural networks, phagocytosis, synapse pruning |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Central nervous system |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Southam, KA (Dr Katherine Southam) |
UTAS Author: | Vincent, AJ (Dr Adele Vincent) |
UTAS Author: | Small, DH (Professor David Small) |
ID Code: | 107616 |
Year Published: | 2016 |
Web of Science® Times Cited: | 14 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2016-03-21 |
Last Modified: | 2017-11-06 |
Downloads: | 116 View Download Statistics |
Repository Staff Only: item control page