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The utilization of antithrombotic therapy in older Australians with atrial fibrillation


Frain, BE and Castelino, R and Bereznicki, L, The utilization of antithrombotic therapy in older Australians with atrial fibrillation, Clinical and Applied Thrombosis/Hemostasis, 23, (6) pp. 671-676. ISSN 1076-0296 (2017) [Refereed Article]

Copyright Statement

Copyright 2016 The Authors

DOI: doi:10.1177/1076029616637184


What is known and Objective: Oral anticoagulants are essential drugs for the prevention of thromboembolic events in patients with atrial fibrillation (AF). Anticoagulants are, however, commonly withheld due to a perceived risk of severe adverse events. The underutilization of anticoagulants in patients with AF has been demonstrated internationally, but to date, there are limited data available in the Australian context. The aim of this study was to determine the utilization patterns of anticoagulants (including novel oral anticoagulants) with respect to stroke and bleeding risk among patients with AF within the community.

Methods: We performed a nonexperimental, retrospective analysis designed to evaluate antithrombotic usage for AF in Australia. The utilization of antithrombotic therapy and the appropriateness of therapy were determined based on CHADS2, CHA2DS2-VASc and HAS-BLED risk stratification schemes. D risk stratification schemes. The presence of documented contraindications was used to determine the appropriateness of antithrombotic therapy.

What is new and Conclusion: Anticoagulants were overutilized in patients at low risk of stroke and underutilized in patients at higher risk of stroke. As the HAS-BLED score increased, the likelihood of patients receiving an anticoagulant decreased regardless of CHADS2 or CHA2DS2-VASc scores.

Item Details

Item Type:Refereed Article
Keywords:atrial fibrillation, elderly, anticoagulants, stroke, thrombosis prophylaxis
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacy and pharmacy practice
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Frain, BE (Ms Bridget Frain)
UTAS Author:Castelino, R (Dr Ronald Castelino)
UTAS Author:Bereznicki, L (Professor Luke Bereznicki)
ID Code:107610
Year Published:2017 (online first 2016)
Web of Science® Times Cited:1
Deposited By:Pharmacy
Deposited On:2016-03-20
Last Modified:2017-12-08

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