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Gender and the active smoking and high-sensitivity C-reactive protein relation in late adolescence
journal contribution
posted on 2023-05-18, 17:59 authored by Le-Ha, C, Beilin, LJ, Burrows, S, Wendy OddyWendy Oddy, Hands, B, Mori, TAC-reactive protein (CRP), smoking, and oral contraceptive (OC) use are associated with CVD risk in adults. This study examines the effect of smoking on high-sensitivity CRP (hs-CRP) levels, and the interactive effects of sex and OC use on this relationship in an adolescent cohort. A total of 1,050 adolescents (mean age 17 ± 0.25 years) from the Western Australian Pregnancy Cohort (Raine) Study had anthropometric, lifestyle, and metabolic measures recorded. The association between smoking status and log-transformed hs-CRP was analyzed using multivariable Tobit linear regression models, with adjustment for adiposity, lifestyle, and early-life confounders. A three-level variable (girls not using OCs, girls using OCs, and boys) was employed to assess the interactive effects of sex, OC use, and smoking. Smoking associated with higher hs-CRP levels in girls not using OCs (b = 0.571; P = 0.001), but not in girls using OCs (b = -0.117; P = 0.598) or in boys (b = 0.183; P = 0.2). OC use in nonsmoking girls was the strongest factor associated with higher hs-CRP levels (b = 1.189; P < 0.001). This study has demonstrated a more robust effect of smoking on hs-CRP levels in girls not using OCs compared with boys. The findings may explain why CVD risk conferred by smoking is higher in women than in men.
History
Publication title
Journal of Lipid ResearchVolume
55Issue
4Pagination
758-764ISSN
0022-2275Department/School
Menzies Institute for Medical ResearchPublisher
Lipid Research IncPlace of publication
9650 Rockville Pike, Bethesda, USA, Md, 20814-3998Repository Status
- Restricted