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Gender and the active smoking and high-sensitivity C-reactive protein relation in late adolescence


Le-Ha, C and Beilin, LJ and Burrows, S and Oddy, WH and Hands, B and Mori, TA, Gender and the active smoking and high-sensitivity C-reactive protein relation in late adolescence, Journal of Lipid Research, 55, (4) pp. 758-764. ISSN 0022-2275 (2014) [Refereed Article]

DOI: doi:10.1194/jlr.P045369


C-reactive protein (CRP), smoking, and oral contraceptive (OC) use are associated with CVD risk in adults. This study examines the effect of smoking on high-sensitivity CRP (hs-CRP) levels, and the interactive effects of sex and OC use on this relationship in an adolescent cohort. A total of 1,050 adolescents (mean age 17 0.25 years) from the Western Australian Pregnancy Cohort (Raine) Study had anthropometric, lifestyle, and metabolic measures recorded. The association between smoking status and log-transformed hs-CRP was analyzed using multivariable Tobit linear regression models, with adjustment for adiposity, lifestyle, and early-life confounders. A three-level variable (girls not using OCs, girls using OCs, and boys) was employed to assess the interactive effects of sex, OC use, and smoking. Smoking associated with higher hs-CRP levels in girls not using OCs (b = 0.571; P = 0.001), but not in girls using OCs (b = -0.117; P = 0.598) or in boys (b = 0.183; P = 0.2). OC use in nonsmoking girls was the strongest factor associated with higher hs-CRP levels (b = 1.189; P < 0.001). This study has demonstrated a more robust effect of smoking on hs-CRP levels in girls not using OCs compared with boys. The findings may explain why CVD risk conferred by smoking is higher in women than in men.

Item Details

Item Type:Refereed Article
Keywords:adolescent smoking, cardiovascular risk factors, oral contraceptives, sex differences
Research Division:Biomedical and Clinical Sciences
Research Group:Nutrition and dietetics
Research Field:Sport and exercise nutrition
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Nutrition
UTAS Author:Oddy, WH (Professor Wendy Oddy)
ID Code:107524
Year Published:2014
Web of Science® Times Cited:10
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-03-17
Last Modified:2017-11-06

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