Khan, HI and Aitken, D and Ding, C and Blizzard, L and Pelletier, JP and Martel-Pelletier, J and Cicuttini, F and Jones, G, Natural history and clinical significance of meniscal tears over 8 years in a midlife cohort, BMC Musculoskeletal Disorders, 17 Article 4. ISSN 1471-2474 (2016) [Refereed Article]
© 2016 Khan et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4) http://creativecommons.org/licenses/by/4.0/
METHODS: One hundred ninety eight participants [mean age 47 (28-63); 57 % female] were studied at baseline and 8 years later. Approximately half were the adult offspring of subjects who had a knee replacement performed for knee OA and the remainder were randomly selected controls. Meniscal tears/extrusion, cartilage volume/defects, bone marrow lesions (BMLs) and effusion were assessed on MRI. Knee pain was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index.
RESULTS: 22 % of the participants had at least one meniscal tear at any site at baseline. Over 8 years, 16 % of the participants had an increase in severity of meniscal tears while none improved. Increase in meniscal tear score was associated with worsening knee pain (β = +2.81 (+1.40, +4.22)), with offspring having a significantly greater increase in pain severity compared to controls. BMI and presence of osteophytes at baseline, but not knee injury, predicted change in tears, whereas change in meniscal tears was independently associated with cartilage volume loss, change in BMLs and change in meniscal extrusion.
CONCLUSION: Change in meniscal tears shares risk factors with knee OA and is independently associated with worsening knee pain and structural damage suggesting that meniscal tears are on the knee OA causal pathway.
|Item Type:||Refereed Article|
|Keywords:||Knee, Osteoarthritis, Magnetic Resonance Imaging, Radiographs, Meniscus|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Khan, HI (Dr Hussain Khan)|
|Author:||Aitken, D (Dr Dawn Aitken)|
|Author:||Ding, C (Professor Chang-Hai Ding)|
|Author:||Blizzard, L (Professor Leigh Blizzard)|
|Author:||Jones, G (Professor Graeme Jones)|
|Web of Science® Times Cited:||1|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||71 View Download Statistics|
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