Zhang, G and Lai, CT and Hartmann, P and Oddy, WH and Kusel, MM and Sly, PD and Holt, PG, Anti-infective proteins in breast milk and asthma-associated phenotypes during early childhood, Pediatric Allergy and Immunology, 25, (6) pp. 544-551. ISSN 0905-6157 (2014) [Refereed Article]
METHODS: As part of a prospective cohort study on the role of respiratory infections in asthma development in high-risk children, we measured the concentration of a panel of anti-infective proteins in maternal milk samples and analyzed associations between these and subsequent atopy-, infection-, and asthma-related outcomes prospectively to age 10 years.
RESULTS: We observed significant but transient inverse associations between the concentration of milk proteins and susceptibility to upper respiratory infections in year 1 only, and parallel but positive transient associations with early lower respiratory infections and atopy. No associations were seen with asthma-related outcomes.
CONCLUSIONS:Breast milk feeding may influence the expression of inflammatory symptoms associated with respiratory infections and atopy in early life, but these effects appear to be inconsistent and transient. The heterogeneous nature of breast-feeding effects suggests it may influence systemic immunoinflammatory function at several different levels.
|Item Type:||Refereed Article|
|Keywords:||IgA, atopy, breast feeding, infancy, lactoferrin, lysozyme, respiratory infection, wheezing|
|Research Division:||Medical and Health Sciences|
|Research Group:||Nutrition and Dietetics|
|Research Field:||Clinical and Sports Nutrition|
|Objective Group:||Public Health (excl. Specific Population Health)|
|Author:||Oddy, WH (Professor Wendy Oddy)|
|Web of Science® Times Cited:||6|
|Deposited By:||Menzies Institute for Medical Research|
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