Rath, SR and Marsh, JA and Newnham, JP and Zhu, K and Atkinson, HC and Mountain, J and Oddy, WH and Hughes, IP and Harris, M and Leong, GM and Cotterill, AM and Sly, PD and Pennell, CE and Choong, CS, Parental pre-pregnancy BMI is a dominant early-life risk factor influencing BMI of offspring in adulthood, Obesity Science & Practice, 2, (1) pp. 48-57. ISSN 2055-2238 (2016) [Refereed Article]
© 2016 The Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/
Methods: Data were analysed on 1355 participants from the Western Australian Pregnancy Cohort (Raine) Study, with anthropometry collected during pregnancy, at birth, one year and at three yearly intervals thereafter. Multivariate analyses and cross-sectional logistic regression quantified the timing and contribution of early-life risk factors for overweight and obesity in young-adulthood.
Results: At five years of age 12.6% of children were overweight and 5.2% were obese. By early adulthood, the prevalence of obesity had increased to 12.8%, whilst overweight remained relatively stable at 14.2% (range from early childhood to adulthood 11–16%). Parental pre-pregnancy body mass index (BMI) was the strongest determinant of adult offspring BMI. Although rapid first year weight gain was associated with increased offspring BMI, the impact of first year weight-gain diminished over childhood, whilst the impact of parental BMI increased over time.
Conclusions: Parental pre-pregnancy BMI and rapid early-life weight gain predispose offspring to obesity in adulthood.
|Item Type:||Refereed Article|
|Keywords:||BMI, early-life, Raine cohort|
|Research Division:||Medical and Health Sciences|
|Research Group:||Nutrition and Dietetics|
|Research Field:||Nutrition and Dietetics not elsewhere classified|
|Objective Group:||Public Health (excl. Specific Population Health)|
|Author:||Oddy, WH (Professor Wendy Oddy)|
|Web of Science® Times Cited:||1|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||10 View Download Statistics|
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