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The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas
journal contribution
posted on 2023-05-18, 17:45 authored by Vanni CarusoVanni Caruso, Hagglund, MG, Badiali, L, Bagchi, S, Roshanbin, S, Ahmad, T, Schioth, HB, Fredriksson, RThe Rhodopsin family is a class of integral membrane proteins belonging to G protein-coupled receptors (GPCRs). To date, several orphan GPCRs are still uncharacterized and in this study we present an anatomical characterization of the GPR162 protein and an attempt to describe its functional role. Our results show that GPR162 is widely expressed in GABAergic as well as other neurons within the mouse hippocampus, whereas extensive expression is observed in areas related to energy homeostasis and hedonic feeding such as hypothalamus, amygdala and ventral tegmental area, regions known to be involved in the regulation of palatable food consumption.
History
Publication title
GeneVolume
553Pagination
1-6ISSN
0378-1119Department/School
School of Pharmacy and PharmacologyPublisher
Elsevier Science BvPlace of publication
NetherlandsRights statement
© 2014 Elsevier B.V. All rights reserved.Repository Status
- Restricted