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The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas

Citation

Caruso, V and Hagglund, MG and Badiali, L and Bagchi, S and Roshanbin, S and Ahmad, T and Schioth, HB and Fredriksson, R, The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas, Gene, 553, (1) pp. 1-6. ISSN 0378-1119 (2014) [Professional, Refereed Article]


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DOI: doi:10.1016/j.gene.2014.09.042

Abstract

The Rhodopsin family is a class of integral membrane proteins belonging to G protein-coupled receptors (GPCRs). To date, several orphan GPCRs are still uncharacterized and in this study we present an anatomical characterization of the GPR162 protein and an attempt to describe its functional role. Our results show that GPR162 is widely expressed in GABAergic as well as other neurons within the mouse hippocampus, whereas extensive expression is observed in areas related to energy homeostasis and hedonic feeding such as hypothalamus, amygdala and ventral tegmental area, regions known to be involved in the regulation of palatable food consumption.

Item Details

Item Type:Professional, Refereed Article
Keywords:GPCRs, food intake, glucose homeostasis, hedonic feeding
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Analytical Biochemistry
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Blood Disorders
Author:Caruso, V (Dr Vanni Caruso)
ID Code:107311
Year Published:2014
Web of Science® Times Cited:2
Deposited By:Pharmacy
Deposited On:2016-03-09
Last Modified:2016-03-18
Downloads:0

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