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Maternal Cigarette Smoke Exposure Contributes to Glucose Intolerance and Decreased Brain Insulin Action in Mice Offspring Independent of Maternal Diet

Citation

Chen, H and Iglesias, MA and Caruso, V and Morris, MJ, Maternal Cigarette Smoke Exposure Contributes to Glucose Intolerance and Decreased Brain Insulin Action in Mice Offspring Independent of Maternal Diet, PL o S One, 6, (11) Article e27260. ISSN 1932-6203 (2011) [Professional, Refereed Article]


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DOI: doi:10.1371/journal.pone.0027260

Abstract

BACKGROUND: Maternal smoking leads to intrauterine undernutrition and is associated with low birthweight and higher risk of offspring obesity. Intrauterine smoke exposure (SE) may alter neuroendocrine mediators regulating energy homeostasis as chemicals in cigarette smoke can reach the fetus. Maternal high-fat diet (HFD) consumption causes fetal overnutrition; however, combined effects of HFD and SE are unknown. Thus we investigated the impact of combined maternal HFD and SE on adiposity and energy metabolism in offspring.

METHOD: Female Balb/c mice had SE (2 cigarettes/day, 5 days/week) or were sham exposed for 5 weeks before mating. Half of each group was fed HFD (33% fat) versus chow as control. The same treatment continued throughout gestation and lactation. Female offspring were fed chow after weaning and sacrificed at 12 weeks.

RESULTS: Birthweights were similar across maternal groups. Faster growth was evident in pups from SE and/or HFD dams before weaning. At 12 weeks, offspring from HFD-fed dams were significantly heavier than those from chow-fed dams (chow-sham 17.60.3 g; chow-SE 17.80.2 g; HFD-sham 18.70.3 g; HFD-SE 18.80.4 g, P<0.05 maternal diet effect); fat mass was significantly greater in offspring from chow+SE, HFD+SE and HFD+sham dams. Both maternal HFD and SE affected brain lactate transport. Glucose intolerance and impaired brain response to insulin were observed in SE offspring, and this was aggravated by maternal HFD consumption.

CONCLUSION: While maternal HFD led to increased body weight in offspring, maternal SE independently programmed adverse health outcomes in offspring. A smoke free environment and healthy diet during pregnancy is desirable to optimize offspring health.

Item Details

Item Type:Professional, Refereed Article
Keywords:GPCRs, food intake, glucose homeostasis, hedonic feeding
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Analytical Biochemistry
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Blood Disorders
Author:Caruso, V (Dr Vanni Caruso)
ID Code:107250
Year Published:2011
Web of Science® Times Cited:16
Deposited By:Pharmacy
Deposited On:2016-03-08
Last Modified:2016-03-09
Downloads:0

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