Ayonrinde, OT and Olynyk, JK and Marsh, JA and Beilin, LJ and Mori, TA and Oddy, WH and Adams, LA, Childhood adiposity trajectories and risk of nonalcoholic fatty liver disease in adolescents, Journal of Gastroenterology and Hepatology, 30, (1) pp. 163-171. ISSN 0815-9319 (2015) [Refereed Article]
METHODS: Assessment for NAFLD, using questionnaires and liver ultrasound, was performed on 1170 adolescents, aged 17 years, from the population-based Raine cohort. We sought associations between NAFLD in adolescents and serial anthropometric measurements recorded from birth, childhood, and adolescence.
RESULTS: NAFLD was diagnosed in 15.2% of adolescents. Birth anthropometry, including birth weight, skinfold thickness, and ponderal index, was not associated with NAFLD. However, adiposity differences between 17-year-old adolescents with NAFLD and those without NAFLD were apparent from age 3 years. Greater adiposity trajectories for weight, body mass index, skinfold thickness, mid-arm circumference, and chest circumference from age 3 years onwards, particularly in males, were associated with the diagnosis of NAFLD and severity of hepatic steatosis at age 17 years (P < 0.05). The strength of the associations increased with age after 3 years for each adiposity measure (all P < 0.001).
CONCLUSIONS: Trajectories of childhood adiposity are associated with NAFLD. Adiposity attained by 3 years of age and older, but not at birth, was associated with the diagnosis and severity of hepatic steatosis in late adolescence. Exploration of clinically relevant risk factors and preventative measures for NAFLD should begin during childhood.
|Item Type:||Refereed Article|
|Keywords:||anthropometry, body mass index, cohort study, nonalcoholic fatty liver disease, skinfold thickness|
|Research Division:||Medical and Health Sciences|
|Research Group:||Nutrition and Dietetics|
|Research Field:||Public Nutrition Intervention|
|Objective Group:||Public Health (excl. Specific Population Health)|
|Author:||Oddy, WH (Professor Wendy Oddy)|
|Web of Science® Times Cited:||15|
|Deposited By:||Menzies Institute for Medical Research|
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