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Low density lipoprotein receptor related proteins as regulators of neural stem and progenitor cell function
Citation
Auderset, L and Landowski, LM and Foa, L and Young, KM, Low density lipoprotein receptor related proteins as regulators of neural stem and progenitor cell function, Stem Cells International Article 2108495. ISSN 1687-9678 (2016) [Refereed Article]
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Copyright Statement
Copyright 2016 Loic Auderset et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Abstract
The central nervous system (CNS) is a highly organised structure. Many signalling systems work in concert to ensure that neural stem cells are appropriately directed to generate progenitor cells, which in turn mature into functional cell types including projection neurons, interneurons, astrocytes, and oligodendrocytes. Herein we explore the role of the low density lipoprotein (LDL) receptor family, in particular family members LRP1 and LRP2, in regulating the behaviour of neural stem and progenitor cells during development and adulthood. The ability of LRP1 and LRP2 to bind a diverse and extensive range of ligands, regulate ligand endocytosis, recruit nonreceptor tyrosine kinases for direct signal transduction and signal in conjunction with other receptors, enables them to modulate many crucial neural cell functions.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | low density lipoprotein receptor related protein (LRP), neural stem cell, oligodendrocyte progenitor cell, neuroblast, central nervous system |
| Research Division: | Medical and Health Sciences |
| Research Group: | Neurosciences |
| Research Field: | Cellular Nervous System |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding Knowledge |
| Objective Field: | Expanding Knowledge in the Biological Sciences |
| Author: | Auderset, L (Mr Loic Auderset) |
| Author: | Landowski, LM (Dr Lila Landowski) |
| Author: | Foa, L (Professor Lisa Foa) |
| Author: | Young, KM (Dr Kaylene Young) |
| ID Code: | 107178 |
| Year Published: | 2016 |
| Funding Support: | National Health and Medical Research Council (1066025) |
| Web of Science® Times Cited: | 11 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2016-03-07 |
| Last Modified: | 2017-11-06 |
| Downloads: | 61 View Download Statistics |
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