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The central nervous system (CNS) is a highly organised structure. Many signalling systems work in concert to ensure that neural stem cells are appropriately directed to generate progenitor cells, which in turn mature into functional cell types including projection neurons, interneurons, astrocytes, and oligodendrocytes. Herein we explore the role of the low density lipoprotein (LDL) receptor family, in particular family members LRP1 and LRP2, in regulating the behaviour of neural stem and progenitor cells during development and adulthood. The ability of LRP1 and LRP2 to bind a diverse and extensive range of ligands, regulate ligand endocytosis, recruit nonreceptor tyrosine kinases for direct signal transduction and signal in conjunction with other receptors, enables them to modulate many crucial neural cell functions.

Item Type:	Refereed Article
Keywords:	low density lipoprotein receptor related protein (LRP), neural stem cell, oligodendrocyte progenitor cell, neuroblast, central nervous system
Research Division:	Biomedical and Clinical Sciences
Research Group:	Neurosciences
Research Field:	Cellular nervous system
Objective Division:	Expanding Knowledge
Objective Group:	Expanding knowledge
Objective Field:	Expanding knowledge in the biological sciences
UTAS Author:	Auderset, L (Mr Loic Auderset)
UTAS Author:	Landowski, LM (Dr Lila Landowski)
UTAS Author:	Foa, L (Professor Lisa Foa)
UTAS Author:	Young, KM (Associate Professor Kaylene Young)
ID Code:	107178
Year Published:	2016
Funding Support:	National Health and Medical Research Council (1066025)
Web of Science® Times Cited:	17
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2016-03-07
Last Modified:	2019-06-26
Downloads:	153 View Download Statistics