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Devil facial tumor disease

Citation

Pye, R and Woods, GM and Kreiss, A, Devil facial tumor disease, Veterinary Pathology, 53, (4) pp. 726-736. ISSN 0300-9858 (2016) [Refereed Article]

Copyright Statement

Copyright The Authors 2015

DOI: doi:10.1177/0300985815616444

Abstract

Devil facial tumor disease (DFTD) is an emergent transmissible cancer exclusive to Tasmanian devils (Sarcophilus harrisii) and threatening the species with extinction in the wild. Research on DFTD began 10 years ago, when nothing was known about the tumor and little about the devils. The depth of knowledge gained since then is impressive, with research having addressed significant aspects of the disease and the devilsí responses to it. These include the cause and pathogenesis of DFTD, the immune response of the devils and the immune evasion mechanisms of the tumor, the transmission patterns of DFTD, and the impacts of DFTD on the ecosystem. This review aims to collate this information and put it into the context of conservation strategies designed to mitigate the impacts of DFTD on the devil and the Tasmanian ecosystem.

Item Details

Item Type:Refereed Article
Keywords:Tasmanian devil, devil facial tumor disease, transmissible cancer, immune response, genetics, Schwann cell, allograft, immune evasion, tumor escape
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Cellular Immunology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Immune System and Allergy
Author:Pye, R (Dr Ruth Pye)
Author:Woods, GM (Professor Gregory Woods)
Author:Kreiss, A (Dr Alexandre Kreiss)
ID Code:107017
Year Published:2016 (online first 2015)
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-03-01
Last Modified:2017-11-07
Downloads:0

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