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Electrokinetic size and mobility traps for on-site therapeutic drug monitoring
Citation
Shallan, AI and Guijt, RM and Breadmore, MC, Electrokinetic size and mobility traps for on-site therapeutic drug monitoring, Angewandte Chemie International Edition, 54, (25) pp. 7359-7362. ISSN 1433-7851 (2015) [Refereed Article]
Copyright Statement
Copyright 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: doi:10.1002/anie.201501794
Abstract
The extraction of target analytes from biological samples is a bottleneck in analysis. A microfluidic device featuring an electrokinetic size and mobility trap was formed by two nanojunctions of different pore size to extract and concentrate analytical targets from complex samples. The trap was seamlessly coupled with electrophoretic separation for quantitative analysis. The device was applied to the analysis of ampicillin levels in blood within 5 min and a linear response over the range of 2.5–20 μg mL−1. This covers the recommended levels for treating sepsis, a critical condition with 30 to 50 % mortality and unpredicted drug levels. The device provides a new opportunity for on-site therapeutic drug monitoring, which should enable quick and accurate dosing and may save lives in such critical conditions.
Item Details
Item Type: | Refereed Article |
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Keywords: | electrophoresis, microfluidics, lab on a chip |
Research Division: | Chemical Sciences |
Research Group: | Analytical chemistry |
Research Field: | Separation science |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the chemical sciences |
UTAS Author: | Shallan, AI (Ms Aliaa Shallan) |
UTAS Author: | Guijt, RM (Dr Rosanne Guijt) |
UTAS Author: | Breadmore, MC (Professor Michael Breadmore) |
ID Code: | 106968 |
Year Published: | 2015 |
Funding Support: | Australian Research Council (FT130100101) |
Web of Science® Times Cited: | 11 |
Deposited By: | Chemistry |
Deposited On: | 2016-02-28 |
Last Modified: | 2017-10-31 |
Downloads: | 0 |
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