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Electrokinetic size and mobility traps for on-site therapeutic drug monitoring
journal contribution
posted on 2023-05-18, 17:25 authored by Shallan, AI, Rosanne Guijt, Michael BreadmoreMichael BreadmoreThe extraction of target analytes from biological samples is a bottleneck in analysis. A microfluidic device featuring an electrokinetic size and mobility trap was formed by two nanojunctions of different pore size to extract and concentrate analytical targets from complex samples. The trap was seamlessly coupled with electrophoretic separation for quantitative analysis. The device was applied to the analysis of ampicillin levels in blood within 5 min and a linear response over the range of 2.5–20 μg mL−1. This covers the recommended levels for treating sepsis, a critical condition with 30 to 50 % mortality and unpredicted drug levels. The device provides a new opportunity for on-site therapeutic drug monitoring, which should enable quick and accurate dosing and may save lives in such critical conditions.
Funding
Australian Research Council
History
Publication title
Angewandte Chemie International EditionVolume
54Issue
25Pagination
7359-7362ISSN
1433-7851Department/School
School of Natural SciencesPublisher
Wiley-V C H Verlag GmbhPlace of publication
Po Box 10 11 61, Weinheim, Germany, D-69451Rights statement
Copyright 2015 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimRepository Status
- Restricted