eCite Digital Repository

Endothelial to mesenchymal transition (EndMT): an active process in Chronic Obstructive Pulmonary Disease (COPD)?

Citation

Sohal, SS, Endothelial to mesenchymal transition (EndMT): an active process in Chronic Obstructive Pulmonary Disease (COPD)?, Respiratory Research (Print), 17, (20) pp. 1-4. ISSN 1465-9921 (2016) [Letter or Note in Journal]


Preview
PDF
Pending copyright assessment - Request a copy
574Kb
  

DOI: doi:10.1186/s12931-016-0337-4

Abstract

Small airway fibrosis is the main contributor to physiological airway dysfunction in COPD. One potential mechanism contributing to small airway fibrosis is epithelial mesenchymal transition (EMT). When associated with angiogenesis (so called EMT-Type-3) it may well also be the link with the development of airway epithelial cancer, which is closely associated with COPD and predominantly in large airways. In a recent study published in Respiratory Research, Reimann and colleagues, showed increased expression of S100A4 in vasculature of human COPD and murine lungs. It is quite possible that the process of endothelial to mesenchymal transition (EndMT) is active in COPD lungs which we wish to comment on.

Item Details

Item Type:Letter or Note in Journal
Keywords:COPD, EMT, EndMT, Lung cancer, Fibrosis
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:106821
Year Published:2016
Web of Science® Times Cited:6
Deposited By:Health Sciences
Deposited On:2016-02-23
Last Modified:2016-02-24
Downloads:0

Repository Staff Only: item control page