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Antiretroviral adherence and treatment outcomes among adult Ethiopian patients
Citation
Bezabhe, WM and Chalmers, L and Bereznicki, LR and Gee, P and Peterson, GM, Antiretroviral adherence and treatment outcomes among adult Ethiopian patients, Aids Care, 28, (8) pp. 1018-1022. ISSN 0954-0121 (2016) [Refereed Article]
Copyright Statement
© 2016 Taylor & Francis
DOI: doi:10.1080/09540121.2016.1139039
Abstract
Developing appropriate strategies to sustain optimal medication adherence among the increasing number of HIV-positive patients taking antiretroviral therapy (ART) in sub-Saharan Africa is a major challenge. The objective of this study was to determine patient, regimen, disease, patient-provider, and healthcare-related factors associated with adherence with ART over a one-year period, and assess the impact of adherence on treatment outcomes. We performed a prospective, observational study among 246 patients who were initiated on ART in Ethiopia. Of 172 who completed follow-up, 130 (75.6%) had ≥ 95% adherence. In the multivariate analyses, a higher baseline BMI (OR, 1.2; 95% CI 1.0, 1.4) and use of reminder devices (OR, 9.1; 95% CI 2.0, 41.6) remained positively associated with adherence, while a higher HIV symptom and adverse drug reaction distress score was an independent negative predictor of adherence (OR, 0.90; 95% CI 0.9, 1.0) CD4 count increase was significantly higher in the adherent patients compared to non-adherent patients at 12 months (159 cells/µL [interquartile range (IQR), 72–324 cells/µL] vs. 132 cells/µL [IQR, 43–190 cells/µL]; p = 0.026). Our findings indicate that interventions aimed at improving adherence and thereby treatment outcomes in patients initiated on ART should promote the use of reminder devices, and monitor HIV symptoms and adverse reaction distress and nutritional status.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | antiretroviral therapy, highly active, medication adherence, HIV, treatment outcomes, Ethiopia |
| Research Division: | Medical and Health Sciences |
| Research Group: | Pharmacology and Pharmaceutical Sciences |
| Research Field: | Clinical Pharmacy and Pharmacy Practice |
| Objective Division: | Health |
| Objective Group: | Other Health |
| Objective Field: | Health not elsewhere classified |
| Author: | Bezabhe, WM (Mr Woldesellassie Bezabhe) |
| Author: | Chalmers, L (Dr Leanne Chalmers) |
| Author: | Bereznicki, LR (Professor Luke Bereznicki) |
| Author: | Gee, P (Mr Peter Gee) |
| Author: | Peterson, GM (Professor Gregory Peterson) |
| ID Code: | 106756 |
| Year Published: | 2016 |
| Web of Science® Times Cited: | 2 |
| Deposited By: | Pharmacy |
| Deposited On: | 2016-02-19 |
| Last Modified: | 2017-11-03 |
| Downloads: | 0 |
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