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ABC transporter inhibitors in reversing multidrug resistance to chemotherapy

Citation

Cui, H and Zhang, AJ and Chen, M and Liu, JJ, ABC transporter inhibitors in reversing multidrug resistance to chemotherapy, Current Drug Targets, 16, (12) pp. 1356-1371. ISSN 1389-4501 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 Bentham Science Publishers

DOI: doi:10.2174/1389450116666150330113506

Abstract

The superfamily of human ATP-binding cassette (ABC) transporters comprises seven subfamilies (ABCA to G) with 48 members. In addition to their profound physiological and pharmacological functions, ABC transporters play important roles in instigating multidrug resistance (MDR) in cancer by mediating the efflux of many anticancer drugs, particularly, ABCB1, ABCG2 and ABCC subfamily members. Previous development of ABCB1 transporter inhibitors has provided insights into seeking novel strategies in developing new classes of compound that inhibit ABCB1 and other MDRrelated ABC transporters. We herein review and evaluate current evidence in this area, with an emphasis on experimental and investigational agents that are under preclinical and clinical tests, including tyrosine kinase inhibitors, natural products, microRNAs and novel chemical entities. New strategies targeting ABC transporters in cancer stem cells and future perspectives in this field are also discussed.


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Item Details

Item Type:Refereed Article
Keywords:ABC transporter inhibitor, cancer stem cell, chemotherapy, microRNA, multidrug resistance, tyrosine kinase inhibitor
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Clinical Pharmacology and Therapeutics
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Cui, H (Mr Hao Cui)
Author:Zhang, AJ (Ms Anna Zhang)
Author:Liu, JJ (Dr Johnson Liu)
ID Code:106682
Year Published:2015
Web of Science® Times Cited:9
Deposited By:Pharmacy
Deposited On:2016-02-17
Last Modified:2017-11-02
Downloads:0

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