The anti-thrombotic properties of an anthocyanin-rich Queen Garnet plum juice (QGPJ) and anthocyanin-free prune juice (PJ) were studied in this randomised, double-blind, crossover trial. Twenty-one healthy subjects (M = 10, F = 11) consumed QGPJ, PJ or placebo, 200 mL/day for 28-days followed by a 2-week wash-out period. Only QGPJ supplementation inhibited platelet aggregation induced by ADP (<5%, P = 0.02), collagen (<2.7%, P < 0.001) and arachidonic acid (<4%, P < 0.001); reduced platelet activation-dependent surface-marker P-selectin expression of activated de-granulated platelets (<17.2%, P = 0.04); prolonged activated-partial thromboplastin clotting time (>2.1 s, P = 0.03); reduced plasma-fibrinogen (<7.5%, P = 0.02) and malondialdehyde levels, a plasma biomarker of oxidative stress (P = 0.016). PJ supplementation increased plasma hippuric acid content (P = 0.018). QGPJ or PJ supplementation did not affect blood cell counts, lipid profile, or inflammation markers. Our findings suggest that QGPJ but not PJ has the potential to significantly attenuate thrombosis by reducing platelet activation/hyper-coagulability and oxidative stress.

Item Type:	Refereed Article
Keywords:	anthocyanins, thrombotic risk, platelet activation, plum, Queen-Garnet plum, platelet activity, anti-platelet therapy
Research Division:	Biomedical and Clinical Sciences
Research Group:	Nutrition and dietetics
Research Field:	Sport and exercise nutrition
Objective Division:	Health
Objective Group:	Public health (excl. specific population health)
Objective Field:	Nutrition
UTAS Author:	Stanley, R (Professor Roger Stanley)
ID Code:	106458
Year Published:	2015
Web of Science® Times Cited:	45
Deposited By:	Tasmanian Institute of Agriculture
Deposited On:	2016-02-10
Last Modified:	2017-11-06
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