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Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers
Santhakumar, AB and Kundur, AR and Fanning, K and Netzel, M and Stanley, R and Singh, I, Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers, Journal of Functional Foods, 12 pp. 11-22. ISSN 1756-4646 (2015) [Refereed Article]
Copyright 2015 Elsevier Ltd.
The anti-thrombotic properties of an anthocyanin-rich Queen Garnet plum juice (QGPJ) and anthocyanin-free prune juice (PJ) were studied in this randomised, double-blind, crossover trial. Twenty-one healthy subjects (M = 10, F = 11) consumed QGPJ, PJ or placebo, 200 mL/day for 28-days followed by a 2-week wash-out period. Only QGPJ supplementation inhibited platelet aggregation induced by ADP (<5%, P = 0.02), collagen (<2.7%, P < 0.001) and arachidonic acid (<4%, P < 0.001); reduced platelet activation-dependent surface-marker P-selectin expression of activated de-granulated platelets (<17.2%, P = 0.04); prolonged activated-partial thromboplastin clotting time (>2.1 s, P = 0.03); reduced plasma-fibrinogen (<7.5%, P = 0.02) and malondialdehyde levels, a plasma biomarker of oxidative stress (P = 0.016). PJ supplementation increased plasma hippuric acid content (P = 0.018). QGPJ or PJ supplementation did not affect blood cell counts, lipid profile, or inflammation markers. Our findings suggest that QGPJ but not PJ has the potential to significantly attenuate thrombosis by reducing platelet activation/hyper-coagulability and oxidative stress.
|Item Type:||Refereed Article|
|Keywords:||anthocyanins, thrombotic risk, platelet activation, plum, Queen-Garnet plum, platelet activity, anti-platelet therapy|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Nutrition and dietetics|
|Research Field:||Sport and exercise nutrition|
|Objective Group:||Public health (excl. specific population health)|
|UTAS Author:||Stanley, R (Professor Roger Stanley)|
|Web of Science® Times Cited:||45|
|Deposited By:||Tasmanian Institute of Agriculture|
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