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Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

Citation

MacLeod, MR and McLean, AL and Kyriakopoulou, A and Serghiou, S and de Wilde, A and Sherratt, N and Hirst, T and Hemblade, R and Bahor, Z and Nunes-Fonseca, C and Potluru, A and Thomson, A and Baginskitae, J and Egan, K and Vesterinen, H and Currie, GL and Churilov, L and Howells, DW and Sena, ES, Risk of Bias in Reports of In Vivo Research: A Focus for Improvement, Public Library of Science Biology, 13, (11) Article e1002273. ISSN 1544-9173 (2015) [Refereed Article]


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Copyright 2015 Macleod et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1371/journal.pbio.1002273

Abstract

The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact, and very limited reporting of measures to reduce the risk of bias in publications from leading United Kingdom institutions. Ascertainment of differences between institutions might serve both as a measure of research quality and as a tool for institutional efforts to improve research quality.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Other Medical and Health Sciences
Research Field:Medical and Health Sciences not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Howells, DW (Professor David Howells)
ID Code:106202
Year Published:2015
Web of Science® Times Cited:55
Deposited By:Medicine (Discipline)
Deposited On:2016-02-02
Last Modified:2017-11-06
Downloads:55 View Download Statistics

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