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Targeting mitochondrial function to protect against vision loss


Chhetri, J and Gueven, N, Targeting mitochondrial function to protect against vision loss, Expert Opinion on Emerging Therapeutic Targets, 20, (6) pp. 721-36. ISSN 1472-8222 (2016) [Refereed Article]

Copyright Statement

© 2016 Informa UK Limited, trading as Taylor & Francis Group

DOI: doi:10.1517/14728222.2015.1134489


Introduction: Mitochondria, essential to multicellular life, convert food into ATP to satisfy cellular energy demands. Since different tissues have different energy requirements, mitochondrial density is high in tissues with high metabolic needs, such as the visual system, which is therefore highly susceptible to limited energy supply as a result of mitochondrial dysfunction.

Areas covered: Vision impairment is a common feature of most mitochondrial diseases. At the same time, there is mounting evidence that mitochondrial impairment contributes to the pathogenesis of major eye diseases such as glaucoma and might also be involved in the reported vision impairment in neurodegenerative disorders such as Alzheimerís disease.

Expert opinion: Rather than relying on symptomatic treatment, acknowledging the mitochondrial origin of visual disorders in mitochondrial, neurodegenerative and ocular diseases could lead to novel therapeutics that aim to modulate mitochondrial function in order to protect against vision loss. This approach has already shown some promising clinical results in inherited retinal disorders, which supports the idea that targeting mitochondria could also be a treatment option for other optic neuropathies.

Item Details

Item Type:Refereed Article
Keywords:drugs, eyes, inherited mitochondrial disease, mitochondria, neurodegenerative disease, ocular disease, short-chain quinones, vision, retina, retinopathy, neuropathy, therapy
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biochemistry and metabolomics
Research Field:Medical biochemistry and metabolomics not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Chhetri, J (Ms Jamuna Chhetri)
UTAS Author:Gueven, N (Dr Nuri Guven)
ID Code:106154
Year Published:2016
Web of Science® Times Cited:8
Deposited By:Pharmacy
Deposited On:2016-02-01
Last Modified:2017-11-06

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