Chhetri, J and Gueven, N, Targeting mitochondrial function to protect against vision loss, Expert Opinion on Emerging Therapeutic Targets, 20, (6) pp. 721-36. ISSN 1472-8222 (2016) [Refereed Article]
© 2016 Informa UK Limited, trading as Taylor & Francis Group
Introduction: Mitochondria, essential to multicellular life, convert food into ATP to satisfy cellular energy demands. Since different tissues have different energy requirements, mitochondrial density is high in tissues with high metabolic needs, such as the visual system, which is therefore highly susceptible to limited energy supply as a result of mitochondrial dysfunction.
Areas covered: Vision impairment is a common feature of most mitochondrial diseases. At the same time, there is mounting evidence that mitochondrial impairment contributes to the pathogenesis of major eye diseases such as glaucoma and might also be involved in the reported vision impairment in neurodegenerative disorders such as Alzheimer’s disease.
Expert opinion: Rather than relying on symptomatic treatment, acknowledging the mitochondrial origin of visual disorders in mitochondrial, neurodegenerative and ocular diseases could lead to novel therapeutics that aim to modulate mitochondrial function in order to protect against vision loss. This approach has already shown some promising clinical results in inherited retinal disorders, which supports the idea that targeting mitochondria could also be a treatment option for other optic neuropathies.
|Item Type:||Refereed Article|
|Keywords:||drugs, eyes, inherited mitochondrial disease, mitochondria, neurodegenerative disease, ocular disease, short-chain quinones, vision, retina, retinopathy, neuropathy, therapy|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Medical biochemistry and metabolomics|
|Research Field:||Medical biochemistry and metabolomics not elsewhere classified|
|Objective Division:||Expanding Knowledge|
|Objective Group:||Expanding knowledge|
|Objective Field:||Expanding knowledge in the health sciences|
|UTAS Author:||Chhetri, J (Ms Jamuna Chhetri)|
|UTAS Author:||Gueven, N (Dr Nuri Guven)|
|Web of Science® Times Cited:||8|
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