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Disorder-specific versus transdiagnostic and clinician-guided versus self-guided treatment for major depressive disorder and comorbid anxiety disorders: A randomized controlled trial

Citation

Titov, N and Dear, BF and Staples, LG and Terides, MD and Karin, E and Sheehan, J and Johnston, L and Gandy, M and Fogliati, VJ and Wootton, BM and McEvoy, PM, Disorder-specific versus transdiagnostic and clinician-guided versus self-guided treatment for major depressive disorder and comorbid anxiety disorders: A randomized controlled trial, Journal of Anxiety Disorders, 35 pp. 88-102. ISSN 0887-6185 (2015) [Refereed Article]


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Copyright 2015 The Authors Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/

DOI: doi:10.1016/j.janxdis.2015.08.002

Abstract

Disorder-specific cognitive behavior therapy (DS-CBT) is effective at treating major depressive disorder (MDD) while transdiagnostic CBT (TD-CBT) addresses both principal and comorbid disorders by targeting underlying and common symptoms. The relative benefits of these two models of therapy have not been determined. Participants with MDD (n†=†290) were randomly allocated to receive an internet delivered TD-CBT or DS-CBT intervention delivered in either clinician-guided (CG-CBT) or self-guided (SG-CBT) formats. Large reductions in symptoms of MDD (Cohenís d†≥†1.44; avg. reduction†≥†45%) and moderate-to-large reductions in symptoms of comorbid generalised anxiety disorder (Cohenís d†≥†1.08; avg. reduction†≥†43%), social anxiety disorder (Cohenís d†≥†0.65; avg. reduction†≥†29%) and panic disorder (Cohenís d†≥†0.45; avg. reduction†≥†31%) were found. No marked or consistent differences were observed across the four conditions, highlighting the efficacy of different forms of CBT at treating MDD and comorbid disorders.

Item Details

Item Type:Refereed Article
Keywords:major depressive disorder, anxiety disorders, treatment, transdiagnostic, disorder-specific, self- guided, therapist-guided, internet, 24-month follow-up, randomized controlled trial
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Mental Health
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Mental Health
Author:Wootton, BM (Dr Bethany Wootton)
ID Code:106035
Year Published:2015
Web of Science® Times Cited:17
Deposited By:Psychology
Deposited On:2016-01-25
Last Modified:2016-08-15
Downloads:36 View Download Statistics

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