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Multidimensional capillary electrophoresis


Grochocki, W and Markuszewski, MJ and Quirino, JP, Multidimensional capillary electrophoresis, Electrophoresis, 36, (1) pp. 135-143. ISSN 0173-0835 (2015) [Refereed Article]

Copyright Statement

Copyright 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

DOI: doi:10.1002/elps.201400416


Multidimensional separation where two or more orthogonal displacement mechanisms are combined is a promising approach to increase peak capacity in CE. The combinations allow dramatic improvement of analytical performance since the total peak capacity is given by a product of the peak capacities of all methods. The initial reports were concentrated on the construction of effective connections between capillaries for 2D analysis. Today, 2D and 3D CE systems are now able to separate real complex biological or environmental mixtures with good repeatability, improved resolution with minimal loss of sample. This review will present the developments in the field of multidimensional CE during the last 15 years. The endeavors in this specific field were on the development of interfaces, interface-free techniques including integrated separations, microdevices, and on-line sample concentration techniques to improve detection sensitivity.

Item Details

Item Type:Refereed Article
Keywords:capillary electrophoresis, comprehensive, heartcutting, interfaces, multidimensional separations
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Quirino, JP (Associate Professor Lito Quirino)
ID Code:105932
Year Published:2015
Web of Science® Times Cited:22
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2016-01-20
Last Modified:2017-10-31

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