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Experimental and computational evidence for KOt-Bu-promoted synthesis of oxopyrazino[1,2-a] indoles

Citation

Mahdavi, M and Hassanzadeh-Soureshjan, R and Saeedi, M and Ariafard, A and BabaAhmadi, R and Ranjbar, PR and Shafiee, A, Experimental and computational evidence for KOt-Bu-promoted synthesis of oxopyrazino[1,2-a] indoles, RSC Advances, 5, (123) pp. 101353-101361. ISSN 2046-2069 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 The Royal Society of Chemistry

DOI: doi:10.1039/c5ra17056g

Abstract

A novel series of oxopyrazino[1,2-a]indole derivatives were prepared via a two-step synthetic procedure including a Ugi-four-component reaction followed by the transition metal-free intramolecular hydroamination of Ugi adducts in the presence of KOt-Bu in DMF at room temperature. Density functional theory (DFT) calculations were also performed to elucidate the mechanistic aspects of the reaction.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Other Chemical Sciences
Research Field:Organometallic Chemistry
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Ariafard, A (Associate Professor Alireza Ariafard)
ID Code:105896
Year Published:2015
Web of Science® Times Cited:4
Deposited By:Chemistry
Deposited On:2016-01-19
Last Modified:2017-10-25
Downloads:0

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