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Experimental and computational evidence for KOt-Bu-promoted synthesis of oxopyrazino[1,2-a] indoles
journal contribution
posted on 2023-05-18, 16:02 authored by Mahdavi, M, Hassanzadeh-Soureshjan, R, Saeedi, M, Alireza AriafardAlireza Ariafard, Rasool Babaahmadi, Ranjbar, PR, Shafiee, AA novel series of oxopyrazino[1,2-a]indole derivatives were prepared via a two-step synthetic procedure including a Ugi-four-component reaction followed by the transition metal-free intramolecular hydroamination of Ugi adducts in the presence of KOt-Bu in DMF at room temperature. Density functional theory (DFT) calculations were also performed to elucidate the mechanistic aspects of the reaction.
History
Publication title
RSC AdvancesVolume
5Issue
123Pagination
101353-101361ISSN
2046-2069Department/School
School of Natural SciencesPublisher
Royal Society of ChemistryPlace of publication
United KingdomRights statement
Copyright 2015 The Royal Society of ChemistryRepository Status
- Restricted