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Oral vaccination of first-feeding Atlantic salmon, Salmo salar L., confers greater protection against yersiniosis than immersion vaccination

Citation

Ghosh, B and Nguyen, TD and Crosbie, PBB and Nowak, BF and Bridle, AR, Oral vaccination of first-feeding Atlantic salmon, Salmo salar L., confers greater protection against yersiniosis than immersion vaccination, Vaccine, 34, (5) pp. 599-608. ISSN 0264-410X (2016) [Refereed Article]

Copyright Statement

2015 Elsevier Ltd. All rights reserved.

DOI: doi:10.1016/j.vaccine.2015.12.044

Abstract

Yersinia ruckeri is a ubiquitous pathogen of finfish capable of causing major mortalities in farmed fish stocks. It can be transmitted vertically from parent to progeny as well as horizontally in the water column from both clinically infected fish and asymptomatic carriers, and is consequently capable of infecting fish at early stages of development. Immunisation strategies that can protect small fry are therefore critical for the effective management of fish health, as is the ability to detect covertly infected fish. In this study, first-feeding Atlantic salmon fry (<0.5g) were immunised either by oral administration of a microencapsulated Y. ruckeri vaccine formulation (0.38g initial weight), or via immersion in bacterin suspension (0.26g), with and without a booster immersion vaccination at 1g size. Protection in groups receiving only immersion immunisation did not differ significantly from untreated controls when challenged with Y. ruckeri at approximately 5g size, while orally immunised fish were significantly better protected than untreated controls (F=4.38, df=4,10, P=0.026), with RPS varying between 29.4% (ORAL) and 51% (ORAL+DIP). A quantitative real-time PCR assay was used to successfully detect covertly infected fish among challenge survivors, indicating more than 50% of surviving fish in each group were infected with no significant differences between immunised fish and untreated controls.

Item Details

Item Type:Refereed Article
Keywords:yersiniosis, vaccine, ERM, Atlantic salmon
Research Division:Agricultural and Veterinary Sciences
Research Group:Fisheries Sciences
Research Field:Aquaculture
Objective Division:Animal Production and Animal Primary Products
Objective Group:Fisheries - Aquaculture
Objective Field:Fisheries - Aquaculture not elsewhere classified
Author:Ghosh, B (Dr Bikramjit Ghosh)
Author:Nguyen, TD (Mr Duc Nguyen)
Author:Crosbie, PBB (Dr Philip Crosbie)
Author:Nowak, BF (Professor Barbara Nowak)
Author:Bridle, AR (Dr Andrew Bridle)
ID Code:105874
Year Published:2016
Web of Science® Times Cited:3
Deposited By:Centre for Fisheries and Aquaculture
Deposited On:2016-01-18
Last Modified:2017-05-16
Downloads:0

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