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Recent applications of microchip electrophoresis to biomedical analysis

Citation

Nuchtavorn, N and Suntornsuk, W and Lunte, SM and Suntornsuk, L, Recent applications of microchip electrophoresis to biomedical analysis, Journal of Pharmaceutical and Biomedical Analysis, 113 pp. 72-96. ISSN 0731-7085 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 Elsevier B.V.

DOI: doi:10.1016/j.jpba.2015.03.002

Abstract

Many separation methods have been developed for biomedical analysis, including chromatographic (e.g. high performance liquid chromatography (HPLC) and gas chromatography (GC)) and electrophoretic methods (e.g. gel electrophoresis and capillary electrophoresis (CE)). Among these techniques, CE provides advantages in terms of high separation efficiency, simplicity, low sample and solvent volume consumption, short analysis time and applicability to a wide range of biomedically important substances. Microchip electrophoresis (ME) is a miniaturized platform of CE and is now considered as a simpler and more convenient alternative, which has demonstrated potential in analytical chemistry. High-throughput, cost-effective and portable analysis systems can be developed using ME. The current review describes different separation modes and detectors that have been employed in ME to analyze various classes of biomedical analytes (e.g. pharmaceuticals and related substances, nucleic acids, amino acids, peptides, proteins, antibodies and antigens, carbohydrates, cells, cell components and lysates). Recent applications (during 20102014) in these areas are presented in tables and some significant findings are highlighted.

Item Details

Item Type:Refereed Article
Keywords:microchip electrophoresis, capillary electrophoresis, microfluidics, biomedical analysis, bioactive compounds
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Nuchtavorn, N (Dr Nantana Nuchtavorn)
ID Code:105813
Year Published:2015
Web of Science® Times Cited:31
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2016-01-14
Last Modified:2016-09-20
Downloads:0

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