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Highly ordered monolithic structures by directional freezing and UV-initiated cryopolymerisation. Evaluation as stationary phases in high performance liquid chromatography

Citation

Arrua, RD and Hilder, EF, Highly ordered monolithic structures by directional freezing and UV-initiated cryopolymerisation. Evaluation as stationary phases in high performance liquid chromatography, RSC Advances, 5, (87) pp. 71131-71138. ISSN 2046-2069 (2015) [Refereed Article]


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Copyright 2015 The Authors Licensed under Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) https://creativecommons.org/licenses/by-nc/3.0/

DOI: doi:10.1039/c5ra15114g

Abstract

Rigid aligned polymers were prepared by directional freezing and photo-initiated cryopolymerisation. Poly[poly(ethyleneglycol) diacrylate] (polyPEGDA) and poly(butyl methacrylate-co-ethylene glycol dimethacrylate) [poly(BuMA-co-EDMA)] macroporous polymers were prepared by directional freezing of the polymerisation mixture in liquid nitrogen and photo-initiated polymerisation in the frozen state. The polymerisation mixtures consisted of monomer/s (total monomer concentrations > 25 wt%), dioxane as solvent and 2,2-dimethoxy-2-phenylacetophenone as photo-initiator. The porous properties of the macroporous polymers were tuned by modifying the monomer concentration in the polymerisation mixture and the immersion rate. The results obtained suggest that the freezing of the solvent crystals occurs in the direction of the temperature gradient from the surface of the reactor to its centre rather than in the freezing direction. The aligned polymers were prepared in situ within pre-treated cycloolefin copolymer (COC) tubing and the resulting materials were tested as stationary phases for the separation of biomolecules under reversed-phase and hydrophobic interaction chromatography.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Arrua, RD (Dr Dario Arrua)
Author:Hilder, EF (Professor Emily Hilder)
ID Code:105811
Year Published:2015
Web of Science® Times Cited:6
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2016-01-14
Last Modified:2016-09-06
Downloads:32 View Download Statistics

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