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Interspecies transfer of the penicillin-binding protein 3-encoding gene ftsI between Haemophilus influenzae and Haemophilus haemolyticus can confer reduced susceptibility to β-lactam antimicrobial agents
Citation
Sondergaard, A and Witherden, EA and Norskov-Lauritsen, N and Tristram, SG, Interspecies transfer of the penicillin-binding protein 3-encoding gene ftsI between Haemophilus influenzae and Haemophilus haemolyticus can confer reduced susceptibility to β-lactam antimicrobial agents, Antimicrobial Agents and Chemotherapy, 59, (7) pp. 4339-4342. ISSN 0066-4804 (2015) [Refereed Article]
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Copyright Statement
Copyright 2015 American Society for Microbiology
Abstract
Mutations in ftsI, encoding penicillin-binding protein 3, can cause decreased β-lactam susceptibility in Haemophilus influenzae.
Sequencing of ftsI from clinical strains has indicated interspecies recombination of ftsI between H. influenzae and Haemophilus
haemolyticus. This study documented apparently unrestricted homologous recombination of ftsI between H. influenzae and H.
haemolyticus in vitro. Transfer of ftsI from resistant isolates conferred similar but not identical increases in the MICs of susceptible
strains of H. influenzae and H. haemolyticus.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | penicillin binding protein |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Medical microbiology |
| Research Field: | Medical bacteriology |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Witherden, EA (Dr Elizabeth Witherden) |
| UTAS Author: | Tristram, SG (Dr Stephen Tristram) |
| ID Code: | 105459 |
| Year Published: | 2015 |
| Web of Science® Times Cited: | 8 |
| Deposited By: | Health Sciences |
| Deposited On: | 2016-01-05 |
| Last Modified: | 2017-11-07 |
| Downloads: | 122 View Download Statistics |
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