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Interspecies transfer of the penicillin-binding protein 3-encoding gene ftsI between Haemophilus influenzae and Haemophilus haemolyticus can confer reduced susceptibility to β-lactam antimicrobial agents

Citation

Sondergaard, A and Witherden, EA and Norskov-Lauritsen, N and Tristram, SG, Interspecies transfer of the penicillin-binding protein 3-encoding gene ftsI between Haemophilus influenzae and Haemophilus haemolyticus can confer reduced susceptibility to β-lactam antimicrobial agents, Antimicrobial Agents and Chemotherapy, 59, (7) pp. 4339-4342. ISSN 0066-4804 (2015) [Refereed Article]


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Copyright Statement

Copyright 2015 American Society for Microbiology

DOI: doi:10.1128/AAC.04854-14

Abstract

Mutations in ftsI, encoding penicillin-binding protein 3, can cause decreased β-lactam susceptibility in Haemophilus influenzae. Sequencing of ftsI from clinical strains has indicated interspecies recombination of ftsI between H. influenzae and Haemophilus haemolyticus. This study documented apparently unrestricted homologous recombination of ftsI between H. influenzae and H. haemolyticus in vitro. Transfer of ftsI from resistant isolates conferred similar but not identical increases in the MICs of susceptible strains of H. influenzae and H. haemolyticus.

Item Details

Item Type:Refereed Article
Keywords:penicillin binding protein
Research Division:Medical and Health Sciences
Research Group:Medical Microbiology
Research Field:Medical Bacteriology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Witherden, EA (Ms Elizabeth Witherden)
Author:Tristram, SG (Dr Stephen Tristram)
ID Code:105459
Year Published:2015
Web of Science® Times Cited:4
Deposited By:Health Sciences
Deposited On:2016-01-05
Last Modified:2017-11-07
Downloads:22 View Download Statistics

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