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Synaptic changes induced by melanocortin signalling


Caruso, V and Lagerstrom, MC and Olszewski, PK and Fredriksson, R and Schioth, HB, Synaptic changes induced by melanocortin signalling, Nature Reviews Neuroscience, 15, (2) pp. 98-110. ISSN 1471-003X (2014) [Refereed Article]

Copyright Statement

2014 Macmillan Publishers

DOI: doi:10.1038/nrn3657


The melanocortin system has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its involvement in memory, nociception, mood disorders and addiction. In this Review, we focus on the role of the melanocortin 4 receptor and provide an integrative view of the molecular mechanisms that lead to melanocortin-induced changes in synaptic plasticity within these diverse physiological systems. We also highlight the importance of melanocortin peptides and receptors in chronic pain syndromes, memory impairments, depression and drug abuse, and the possibility of targeting them for therapeutic purposes.

Item Details

Item Type:Refereed Article
Keywords:MC4R, Synaptic Plasticity, Memory, Pain, Addiction.
Research Division:Biological Sciences
Research Group:Biochemistry and cell biology
Research Field:Cell neurochemistry
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Caruso, V (Dr Vanni Caruso)
ID Code:105396
Year Published:2014
Web of Science® Times Cited:57
Deposited By:Pharmacy
Deposited On:2015-12-23
Last Modified:2017-11-06

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