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Synaptic changes induced by melanocortin signalling
journal contribution
posted on 2023-05-18, 15:21 authored by Vanni CarusoVanni Caruso, Lagerstrom, MC, Olszewski, PK, Fredriksson, R, Schioth, HBThe melanocortin system has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its involvement in memory, nociception, mood disorders and addiction. In this Review, we focus on the role of the melanocortin 4 receptor and provide an integrative view of the molecular mechanisms that lead to melanocortin-induced changes in synaptic plasticity within these diverse physiological systems. We also highlight the importance of melanocortin peptides and receptors in chronic pain syndromes, memory impairments, depression and drug abuse, and the possibility of targeting them for therapeutic purposes.
History
Publication title
Nature Reviews NeuroscienceVolume
15Pagination
98-110ISSN
1471-003XDepartment/School
School of Pharmacy and PharmacologyPublisher
Nature Pub. GroupPlace of publication
United KingdomRights statement
© 2014 Macmillan PublishersRepository Status
- Restricted