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Quantitative knee effusion-synovitis assessment in older adults: Associations with knee structural abnormalities

Citation

Wang, X and Blizzard, L and Jin, X and Chen, Z and Zhu, Z and Han, W and Halliday, A and Cicuttini, F and Jones, G and Ding, C, Quantitative knee effusion-synovitis assessment in older adults: Associations with knee structural abnormalities, Arthritis & Rheumatology, 68, (4) pp. 837-844. ISSN 2326-5191 (2015) [Refereed Article]

Copyright Statement

Copyright 2016 American College of Rheumatology

DOI: doi:10.1002/art.39526

Abstract

Objective: To describe the natural history of quantitatively measured knee effusion-synovitis and the longitudinal associations between effusion-synovitis and knee structural factors including cartilage defects, cartilage volume, subchondral bone marrow lesions and meniscal pathology in older adults.

Methods: A total of 406 subjects were randomly selected (mean 62 years, 50% females) at baseline and followed up 2.7 years later. T2 or T1-weighted fat saturation magnetic resonance imaging (MRI) was used to assess knee effusion-synovitis maximal area, cartilage defects, cartilage volume, bone marrow lesions (BMLs) and meniscal pathology at baseline and follow-up. Multivariable generalized linear regressions were performed to analyze the associations between maximal area of effusion-synovitis and other joint structural factors after adjustment for age, gender, BMI, tibial bone area and/or radiographic osteoarthritis.

Results: Over 2.7 years of follow-up, the size of effusion-synovitis increased in 29%, remained stable in 50% and decreased in 22% of the participants. Baseline effusion-synovitis maximal area was significantly associated with changes in knee cartilage defects (β: 0.18, 95%CI: 0.07, 0.29), BMLs (β: 0.17, 95%CI: 0.05, 0.30), and cartilage volume (β: -0.40, 95%CI: -0.71, -0.09) but not with change in meniscal pathology. In contrast, baseline structural measures were not associated with change or increase in effusion-synovitis maximal area.

Conclusion: Knee effusion-synovitis was not static in older adults. It was predictive of, but not predicted by, other structural abnormalities suggesting a potential role in knee early osteoarthritic changes. This article is protected by copyright. All rights reserved.

Item Details

Item Type:Refereed Article
Keywords:effusion-synovitis, natural history, knee osteoarthritis
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Wang, X (Ms Xia Wang)
Author:Blizzard, L (Associate Professor Leigh Blizzard)
Author:Jin, X (Mr Xingzhong Jin)
Author:Chen, Z (Dr Zhongshan Chen)
Author:Zhu, Z (Mr Zhao Zhu)
Author:Han, W (Dr Weiyu Han)
Author:Jones, G (Professor Graeme Jones)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:105324
Year Published:2015
Web of Science® Times Cited:5
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-12-18
Last Modified:2017-11-01
Downloads:2 View Download Statistics

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