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Gait phenotype from mild cognitive impairment to moderate dementia: results from the GOOD initiative


Allali, G and Annweiler, C and Blumen, HM and Callisaya, ML and De Cock, A-M and Kressig, RW and Srikanth, V and Steinmetz, J-P and Verghese, J and Beauchet, O, Gait phenotype from mild cognitive impairment to moderate dementia: results from the GOOD initiative, European Journal of Neurology, 23, (3) pp. 527-541. ISSN 1351-5101 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 EAN

DOI: doi:10.1111/ene.12882


Background and purpose: The differences in gait abnormalities from the earliest to the later stages of dementia and in the different subtypes of dementia have not been fully examined. This study aims to compare spatiotemporal gait parameters in cognitively healthy individuals, patients with amnestic mild cognitive impairment (MCI) and non-amnestic MCI, and patients with mild and moderate stages of Alzheimer's disease (AD) and non-Alzheimer's disease (non-AD).

Methods: Based on a cross-sectional design, 1719 participants (77.4 ± 7.3 years, 53.9% female) were recruited from cohorts from seven countries participating in the Gait, Cognition and Decline (GOOD) initiative. Mean values and coefficients of variation of spatiotemporal gait parameters were measured during normal pace walking with the GAITRite system at all sites.

Results: Performance of spatiotemporal gait parameters declined in parallel with the stage of cognitive decline from MCI status to moderate dementia. Gait parameters of patients with non-amnestic MCI were more disturbed compared to patients with amnestic MCI, and MCI subgroups performed better than demented patients. Patients with non-AD dementia had worse gait performance than those with AD dementia. This degradation of gait parameters was similar between mean values and coefficients of variation of spatiotemporal gait parameters in the earliest stages of cognitive decline, but different in the most advanced stages, especially in the non-AD subtypes.

Conclusions: Spatiotemporal gait parameters were more disturbed in the advanced stages of dementia, and more affected in the non-AD dementias than in AD. These findings suggest that quantitative gait parameters could be used as a surrogate marker for improving the diagnosis of dementia.

Item Details

Item Type:Refereed Article
Keywords:dementia, aging, Alzheimer’s disease, cohort studies, dementia, gait disorders, mild cognitive impairment, motor control, quantitative gait parameters
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Geriatrics and gerontology
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Health related to ageing
UTAS Author:Callisaya, ML (Dr Michele Callisaya)
UTAS Author:Srikanth, V (Dr Velandai Srikanth)
ID Code:105304
Year Published:2015
Web of Science® Times Cited:78
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-12-18
Last Modified:2017-11-06

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