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Cross-sectional and longitudinal associations between knee joint effusion synovitis and knee pain in older adults

Citation

Wang, X and Jin, X and Han, W and Cao, Y and Halliday, A and Blizzard, L and Pan, F and Antony, B and Cicuttini, F and Jones, G and Ding, C, Cross-sectional and longitudinal associations between knee joint effusion synovitis and knee pain in older adults, Journal of Rheumatology, 43, (1) pp. 121-130. ISSN 1499-2752 (2016) [Refereed Article]

Copyright Statement

Copyright 2016 The Journal of Rheumatology

DOI: doi:10.3899/jrheum.150355

Abstract

Objective: To describe the cross-sectional and longitudinal associations between knee regional effusion synovitis and knee pain in older adults.

Methods: Data from a population-based random sample (n = 880, mean age 62 yrs, 50% women) were used. Baseline knee joint effusion synovitis was graded (0-3) using T2-weighted magnetic resonance imaging (MRI) in the suprapatellar pouch, central portion, posterior femoral recess, and subpopliteal recess. Effusion synovitis of the whole joint was defined as a score of ≥ 2 in any subregion. Other knee structural (including cartilage, bone marrow, and menisci) lesions were assessed by MRI at baseline. Knee pain was assessed by the Western Ontario and McMaster Universities Osteoarthritis Index questionnaire at baseline and 2.6 years later. Multivariable analyses were performed after adjustment for age, sex, body mass index, and other structural lesions.

Results: The prevalence of effusion synovitis was 67%. Suprapatellar pouch effusion synovitis was significantly and independently associated with increased total and nonweight-bearing knee pain in both cross-sectional and longitudinal analyses (for an increase in total knee pain of ≥ 5, RR 1.26 per grade, 95% CI 1.04-1.52), and increased weight-bearing knee pain in longitudinal analysis only. Effusion synovitis in posterior femoral recess and central portion were independently associated with increases in nonweight-bearing pain (RR 1.63 per grade, 95% CI 1.32-2.01 and RR 1.29 per grade, 95% CI 1.01-1.65, respectively) in longitudinal analyses only.

Conclusion: Knee joint effusion synovitis has independent associations with knee pain in older adults. Suprapatellar pouch effusion synovitis is associated with nonweight-bearing and weight-bearing knee pain, while posterior femoral recess and central portion effusion synovitis are only associated with nonweight-bearing pain.

Item Details

Item Type:Refereed Article
Keywords:osteoarthritis, effusion, synovitis, knee pain
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Wang, X (Ms Xia Wang)
Author:Jin, X (Mr Xingzhong Jin)
Author:Han, W (Dr Weiyu Han)
Author:Cao, Y (Associate Professor Yue long Cao)
Author:Blizzard, L (Professor Leigh Blizzard)
Author:Pan, F (Professor Faming Pan)
Author:Antony, B (Dr Benny Eathakkattu Antony)
Author:Jones, G (Professor Graeme Jones)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:105281
Year Published:2016 (online first 2015)
Web of Science® Times Cited:9
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-12-17
Last Modified:2017-11-03
Downloads:0

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