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The effect of knowledge and expectations on adherence to and persistence with antidepressants


Woodward, SC and Bereznicki, BJ and Westbury, JL and Bereznicki, LRE, The effect of knowledge and expectations on adherence to and persistence with antidepressants, APSA 2014 Annual Conference, 5-7 December, 2014, Brisbane, Australia (2014) [Conference Extract]

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BACKGROUND: Adherence to and persistence with antidepressants are often suboptimal. However, little is known about how patient knowledge and outcome expectations may influence antidepressant adherence and persistence.

METHODS: Individuals who had been prescribed their first antidepressant to treat depression in the preceding six months were recruited to an online survey via Facebook. Knowledge, education received and initial outcome expectations were analysed for associations with persistence and adherence.

RESULTS: There were 220 surveys analysed. A total of 117 participants had taken their antidepressant for at least three months, while 25 had never started or stopped after less than three months without their doctorís involvement. Differences in expectations and various educational messages amongst persistent and non-persistent participants were identified. The instruction "donít stop it without checking with your doctor" was a significant independent predictor of persistence (OR = 5.9, 95% CI = 1.4-24.5).

At the time of the survey, 82.7% participants were taking an antidepressant and 77.9% were adherent. Significant independent predictors of adherence were a greater age (OR = 1.1, 95% CI = 1.0-1.2), knowledge (OR = 1.6, 95% CI = 1.1-2.3), being informed of common side effects (OR = 5.5, 95% CI = 1.1 29.0) and having discussed ways to solve problems (OR = 3.9, 95% CI = 1.1-14.5).

DISCUSSION: Improving outcome expectations and particular educational messages may increase adherence and persistence. Greater knowledge may help adherence. Further investigation is warranted to investigate whether a focus on these simple educational messages will improve outcomes in patients who commence an antidepressant.

Item Details

Item Type:Conference Extract
Keywords:Antidepressants; Medication adherence; Expectations
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Health services and systems not elsewhere classified
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Preventive medicine
UTAS Author:Woodward, SC (Miss Sophie Woodward)
UTAS Author:Bereznicki, BJ (Dr Bonnie Bereznicki)
UTAS Author:Westbury, JL (Associate Professor Juanita Breen)
UTAS Author:Bereznicki, LRE (Professor Luke Bereznicki)
ID Code:105227
Year Published:2014
Deposited By:Pharmacy
Deposited On:2015-12-15
Last Modified:2015-12-16

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