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Repeated blood pressure measurements in childhood in prediction of hypertension in adulthood


Oikonen, M and Nuotio, J and Magnussen, CG and Viikari, JSA and Taittonen, L and Laitinen, T and Hutri-Kahonen, N and Jokinen, E and Jula, A and Cheung, M and Sabin, MA and Daniels, SR and Raitakari, OT and Juonala, M, Repeated blood pressure measurements in childhood in prediction of hypertension in adulthood, Hypertension, 67, (1) pp. 41-47. ISSN 0194-911X (2016) [Refereed Article]

Copyright Statement

Copyright 2015 American Heart Association, Inc.

DOI: doi:10.1161/HYPERTENSIONAHA.115.06395


Hypertension may be predicted from childhood risk factors. Repeated observations of abnormal blood pressure in childhood may enhance prediction of hypertension and subclinical atherosclerosis in adulthood compared with a single observation. Participants (1927, 54% women) from the Cardiovascular Risk in Young Finns Study had systolic and diastolic blood pressure measurements performed when aged 3 to 24 years. Childhood/youth abnormal blood pressure was defined as above 90th or 95th percentile. After a 21- to 31-year follow-up, at the age of 30 to 45 years, hypertension (>140/90 mm Hg or antihypertensive medication) prevalence was found to be 19%. Carotid intima-media thickness was examined, and high-risk intima-media was defined as intima-media thickness >90th percentile or carotid plaques. Prediction of adulthood hypertension and high-risk intima-media was compared between one observation of abnormal blood pressure in childhood/youth and multiple observations by improved Pearson correlation coefficients and area under the receiver operating curve. When compared with a single measurement, 2 childhood/youth observations improved the correlation for adult systolic (r=0.44 versus 0.35, P<0.001) and diastolic (r=0.35 versus 0.17, P<0.001) blood pressure. In addition, 2 abnormal childhood/youth blood pressure observations increased the prediction of hypertension in adulthood (0.63 for 2 versus 0.60 for 1 observation, P=0.003). When compared with 2 measurements, third observation did not provide any significant improvement for correlation or prediction (P always >0.05). A higher number of childhood/youth observations of abnormal blood pressure did not enhance prediction of adult high-risk intima-media thickness. Compared with a single measurement, the prediction of adult hypertension was enhanced by 2 observations of abnormal blood pressure in childhood/youth.

Item Details

Item Type:Refereed Article
Keywords:atherosclerosis, blood pressure, follow-up studies, hypertension, risk factors
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Magnussen, CG (Associate Professor Costan Magnussen)
ID Code:105179
Year Published:2016
Funding Support:National Health and Medical Research Council (1037559)
Web of Science® Times Cited:48
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-12-11
Last Modified:2022-08-30

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