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Inhibitory dysfunction in amyotrophic lateral sclerosis: future therapeutic opportunities

Citation

Clark, R and Blizzard, C and Dickson, T, Inhibitory dysfunction in amyotrophic lateral sclerosis: future therapeutic opportunities, Neurodegenerative Disease Management, 5, (6) pp. 511-525. ISSN 1758-2024 (2015) [Refereed Article]

DOI: doi:10.2217/nmt.15.49

Abstract

In amyotrophic lateral sclerosis, motor neuron hyperexcitability and inhibitory dysfunction is emerging as a potential causative link in the dysfunction and degeneration of the motoneuronal circuitry that characterizes the disease. Interneurons, as key regulators of excitability, may mediate much of this imbalance, yet we know little about the way in which inhibitory deficits perturb excitability. In this review, we explore inhibitory control of excitability and the potential contribution of altered inhibition to amyotrophic lateral sclerosis disease processes and vulnerabilities, identifying important windows of therapeutic opportunity and potential interventions, specifically targeting inhibitory control at key disease stages.

Item Details

Item Type:Refereed Article
Keywords:amyotrophic lateral sclerosis, excitability, hyperexcitability, hypoexcitability, inhibition, interneuron, motor neuron
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Clark, R (Miss Rosie Clark)
Author:Blizzard, C (Dr Catherine Blizzard)
Author:Dickson, T (Associate Professor Tracey Dickson)
ID Code:105125
Year Published:2015
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-12-08
Last Modified:2017-11-06
Downloads:0

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