File(s) under permanent embargo
Inhibitory dysfunction in amyotrophic lateral sclerosis: future therapeutic opportunities
journal contribution
posted on 2023-05-18, 15:04 authored by Rosemary ClarkRosemary Clark, Catherine BlizzardCatherine Blizzard, Tracey DicksonTracey DicksonIn amyotrophic lateral sclerosis, motor neuron hyperexcitability and inhibitory dysfunction is emerging as a potential causative link in the dysfunction and degeneration of the motoneuronal circuitry that characterizes the disease. Interneurons, as key regulators of excitability, may mediate much of this imbalance, yet we know little about the way in which inhibitory deficits perturb excitability. In this review, we explore inhibitory control of excitability and the potential contribution of altered inhibition to amyotrophic lateral sclerosis disease processes and vulnerabilities, identifying important windows of therapeutic opportunity and potential interventions, specifically targeting inhibitory control at key disease stages.
History
Publication title
Neurodegenerative Disease ManagementVolume
5Issue
6Pagination
511-525ISSN
1758-2024Department/School
Menzies Institute for Medical ResearchPublisher
Future Medicine Ltd.Place of publication
United KingdomRepository Status
- Restricted