Loffler, D and Landgraf, K and Korner, A and Kratzsch, J and Kirkby, KC and Himmerich, E, Modulation of triglyceride accumulation in adipocytes by psychopharmacological agents in vitro, Journal of Psychiatric Research, 72 pp. 37-42. ISSN 0022-3956 (2016) [Refereed Article]
© 2015 Elsevier Ltd. All rights reserved.
Weight gain is a major problem during psychopharmacological treatment. Research has concentrated on the appetite inducing properties and mechanisms of these drugs in the central nervous system. The potential contribution of direct effects of drugs on metabolically relevant peripheral cells such as adipocytes is less well understood.
We examined the influence of the antidepressant imipramine, the antipsychotic clozapine, and the mood stabilizer lithium on preadipocytes and adipocytes in vitro, using Simpson-Golabi-Behmel syndrome (SGBS) cells, an established human preadipocyte model. Parameters of cell differentiation and signaling, and cell metabolism were measured.
We found significantly increased triglyceride accumulation in adipocytes after supplementation with imipramine and lithium at therapeutic concentrations, compared to non-supplemented control samples. However, gene expression levels of an early marker of adipogenesis, the peroxisome proliferator-activated receptor gamma (PPAR-γ) and a late marker of adipogenesis, the fatty acid binding protein 4 (FABP4), as well as expression of adiponectin (ADIPOQ) did not change significantly in the presence of these psychopharmacological agents.
The results suggest a direct influence of imipramine and lithium but not clozapine on fat storage of adipocytes. The underlying mechanisms of fatty acid storage and adipocyte differentiation however remain to be elucidated.
|Item Type:||Refereed Article|
|Keywords:||adipose tissue, adipocytes, Clozapine, Imipramine. lithium, weight gain|
|Research Division:||Health Sciences|
|Research Group:||Health services and systems|
|Research Field:||Mental health services|
|Objective Group:||Public health (excl. specific population health)|
|Objective Field:||Mental health|
|UTAS Author:||Kirkby, KC (Professor Kenneth Kirkby)|
|Web of Science® Times Cited:||9|
Repository Staff Only: item control page