Han, W and Aitken, D and Zhu, Z and Halliday, A and Wang, X and Antony, B and Cicuttini, F and Jones, G and Ding, C, Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study, ARD Online, 75 pp. 1783-1788. ISSN 1468-2060 (2016) [Refereed Article]
Copyright 2015 The Authors
Objective: To describe the associations between infrapatellar fat pad (IPFP) signal intensity alteration at baseline and knee symptoms and structural changes in older adults.
Methods: A total of 874 subjects (mean 62.1 years, 50.1% female) selected randomly from local community were studied at baseline and 770 were followed up (only 357 had MRI at follow-up) over 2.6 years. T1-weighted or T2-weighted fat suppressed MRI was used to assess IPFP signal intensity alteration (0-3), cartilage volume, cartilage defects and bone marrow lesions (BMLs) at baseline and 2.6 years later. Knee pain was assessed by self-administered Western Ontario and McMaster Osteoarthritis Index questionnaire. Radiographic osteoarthritis (OA) was assessed.
Results: In cross-sectional analyses, IPFP signal intensity alteration was significantly and positively associated with total knee pain as well as knee cartilage defects, BMLs and knee radiographic OA and negatively associated with patellar cartilage volume after adjustment for age, sex, body mass index and/or radiographic OA. Longitudinally, baseline signal intensity alteration within IPFP was significantly and positively associated with increases in knee pain when going upstairs/downstairs as well as increases in tibiofemoral cartilage defects and BMLs, and negatively associated with change in lateral tibial cartilage volume in multivariable analyses.
Conclusions: IPFP signal intensity alteration at baseline was associated with knee structural abnormalities and clinical symptoms cross-sectionally and longitudinally in older adults, suggesting that it may serve as an important imaging biomarker in knee OA.
|Item Type:||Refereed Article|
|Keywords:||inflammation, knee osteoarthritis, magnetic resonance imaging|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Han, W (Dr Weiyu Han)|
|Author:||Aitken, D (Dr Dawn Aitken)|
|Author:||Zhu, Z (Mr Zhao Zhu)|
|Author:||Wang, X (Ms Xia Wang)|
|Author:||Antony, B (Mr Benny Eathakkattu Antony)|
|Author:||Jones, G (Professor Graeme Jones)|
|Author:||Ding, C (Professor Chang-Hai Ding)|
|Year Published:||2016 (online first 2015)|
|Web of Science® Times Cited:||11|
|Deposited By:||Menzies Institute for Medical Research|
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