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Brachial-to-radial systolic blood pressure amplification in patients with type 2 diabetes mellitus


Climie, RED and Picone, DS and Keske, MA and Sharman, JE, Brachial-to-radial systolic blood pressure amplification in patients with type 2 diabetes mellitus, Journal of Human Hypertension, 30 pp. 404-409. ISSN 1476-5527 (2016) [Refereed Article]

Copyright Statement

Copyright 2015 Macmillan Publishers Limited

DOI: doi:10.1038/jhh.2015.101


Brachial-to-radial-systolic blood pressure amplification (Bra-Rad-SBPAmp) can affect central SBP estimated by radial tonometry. Patients with type 2 diabetes mellitus (T2DM) have vascular irregularities that may alter Bra-Rad-SBPAmp. By comparing T2DM with non-diabetic controls, we aimed to determine the (1) magnitude of Bra-Rad-SBPAmp; (2) haemodynamic factors related to Bra-Rad-SBPAmp; and (3) effect of Bra-Rad-SBPAmp on estimated central SBP. Twenty T2DM (64 ± 8 years) and 20 non-diabetic controls (60 ± 8 years; 50% male both) underwent simultaneous cuff deflation and two-dimensional ultrasound imaging of the brachial and radial arteries. The first Korotkoff sound (denoting SBP) was identified from the first inflection point of Doppler flow during cuff deflation. Bra-Rad-SBPAmp was calculated by radial minus brachial SBP. Upper limb and systemic haemodynamics were recorded by tonometry and ultrasound. Radial SBP was higher than brachial SBP for T2DM (136 ± 19 vs 127 ± 17 mm Hg; P < 0.001) and non-diabetic controls (135 ± 12 vs 121 ± 11 mm Hg; P < 0.001), but Bra-Rad-SBPAmp was significantly lower in T2DM (9 ± 8 vs 14 ± 7 mm Hg; P = 0.042). The product of brachial mean flow velocity × brachial diameter was inversely and independently correlated with Bra-Rad-SBPAmp in T2DM (β = −0.033 95% confidence interval −0.063 to −0.004, P = 0.030). When radial waveforms were calibrated using radial, compared with brachial SBP, central SBP was significantly higher in both groups (T2DM, 116 ± 13 vs 125 ± 15 mm Hg; and controls, 112 ± 10 vs 124 ± 11 mm Hg; P < 0.001 both) and there was a significant increase in the number of participants classified with ‘central hypertension’ (SBP ≫ 130 mm Hg; P = 0.004). Compared with non-diabetic controls, Bra-Rad-SBPAmp is significantly lower in T2DM. Regardless of disease status, radial SBP is higher than brachial SBP and this results in underestimation of central SBP using brachial-BP-calibrated radial tonometry.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Climie, RED (Dr Rachel Climie)
UTAS Author:Picone, DS (Dr Dean Picone)
UTAS Author:Keske, MA (Dr Michelle Keske)
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:104926
Year Published:2016 (online first 2015)
Web of Science® Times Cited:7
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-11-26
Last Modified:2017-11-03

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