Hartiala, O and Magnussen, CG and Bucci, M and Kajander, S and Knuuti, J and Ukkonen, H and Saraste, A and Rinta-Kiikka, I and Kainulainen, S and Kahonen, M and Hutri-Kahonen, N and Laitinen, T and Lehtimaki, T and Viikari, JSA and Hartiala, J and Juonala, M and Raitakari, OT, Coronary heart disease risk factors, coronary artery calcification and epicardial fat volume in the Young Finns Study, European Heart Journal - Cardiovascular Imaging, 16, (11) pp. 1256-1263. ISSN 2047-2404 (2015) [Refereed Article]
Copyright 2015 The Author
Aims: We investigated associations of pre-clinical coronary heart disease (CHD), adolescence and adulthood CHD risk factors, and epicardial fat volume (EFV), which is thought to influence CHD pathology.
Methods and results: EFV and coronary calcium scores were quantified using computed tomography imaging for 557 subjects from the Cardiovascular Risk in Young Finns Study in 2007. CHD risk marker levels were assessed repeatedly from 1980 to 2007. Carotid intima-media thickness (cIMT), carotid distensibility, and brachial flow-mediated dilatation were measured by vascular ultrasound in 2007. Increased EFV was cross-sectionally associated with male sex, increased waist circumference, body-mass index (BMI), cIMT, metabolic syndrome prevalence, levels of apolipoprotein B, total cholesterol, low-density lipoprotein cholesterol, triglycerides, C-reactive protein, blood pressure, insulin, and fasting glucose, as well as ever smoking, alcoholic intake, and lower high-density lipoprotein cholesterol (HDL-C), carotid distensibility and physical activity in adulthood. In BMI-adjusted analyses, only apolipoprotein B, ever smoking, alcohol intake and metabolic syndrome prevalence were independently associated with EFV. In adolescence, skinfold thickness, BMI, and insulin levels were higher and HDL-C lower with increasing EFV. Subjects in the lowest vs. highest quarter of EFV had consistently lower BMI across the early life-course.
Conclusion: Associations of CHD risk markers with EFV were attenuated after multivariable adjustment. We found no evidence of increased EFV being independently associated with pre-clinical atherosclerosis. EFV was most strongly associated with BMI and waist circumference. Subjects with higher EFV had consistently higher BMI from age 12 suggesting that life-long exposure to higher BMI influences the development of EFV.
|Item Type:||Refereed Article|
|Keywords:||atherosclerosis, epicardial fat, risk factors, coronary artery calcium|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Magnussen, CG (Dr Costan Magnussen)|
|Funding Support:||National Health and Medical Research Council (1037559)|
|Web of Science® Times Cited:||4|
|Deposited By:||Menzies Institute for Medical Research|
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