Climie, RED and Moran, C and Callisaya, M and Blizzard, L and Sharman, JE and Venn, A and Phan, TG and Beare, R and Forbes, J and Blackburn, NB and Srikanth, V, Abdominal obesity and brain atrophy in type 2 diabetes mellitus, PLoS One, 10, (11) Article e0142589. ISSN 1932-6203 (2015) [Refereed Article]
© 2015 Climie et al. Licenced under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/
Official URL: http://dx.doi.org/0.1371/journal.pone.0142589
Aim: Type 2 diabetes mellitus (T2D) is associated with gray matter atrophy. Adiposity and physical inactivity are risk factors for T2D and brain atrophy. We studied whether the associations of T2D with total gray matter volume (GMV) and hippocampal volume (HV) are dependent on obesity and physical activity.
Materials and Methods: In this cross-sectional study, we measured waist-hip ratio (WHR), body mass index (BMI), mean steps/day and brain volumes in a community dwelling cohort of people with and without T2D. Using multivariable linear regression, we examined whether WHR, BMI and physical activity mediated or modified the association between T2D, GMV and HV.
Result: There were 258 participants with (mean age 67±7 years) and 302 without (mean age 72 ± 7 years) T2D. Adjusting for age, sex and intracranial volume, T2D was independently associated with lower total GMV (p = 0.001) and HV (p < 0.001), greater WHR (p < 0.001) and BMI (p < 0.001), and lower mean steps/day (p = 0.002). After adjusting for covariates, the inclusion of BMI and mean steps/day did not significantly affect the T2D-GMV association, but WHR attenuated it by 32% while remaining independently associated with lower GMV (p < 0.01). The T2D-HV association was minimally changed by the addition of BMI, steps/day or WHR in the model. No statistical interactions were observed between T2D and measures of obesity and physical activity in explaining brain volumes.
Conclusions: Abdominal obesity or its downstream effects may partially mediate the adverse effect of T2D on brain atrophy. This requires confirmation in longitudinal studies.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Climie, RED (Miss Rachel Climie)|
|Author:||Callisaya, M (Dr Michele Callisaya)|
|Author:||Blizzard, L (Professor Leigh Blizzard)|
|Author:||Sharman, JE (Professor James Sharman)|
|Author:||Venn, A (Professor Alison Venn)|
|Author:||Blackburn, NB (Mr Nicholas Blackburn)|
|Author:||Srikanth, V (Dr Velandai Srikanth)|
|Web of Science® Times Cited:||5|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||94 View Download Statistics|
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