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Vascular and metabolic actions of the green tea polyphenol epigallocatechin gallate

Citation

Keske, MA and Ng, HLH and Premilovac, D and Rattigan, S and Kim, J and Munir, K and Yang, P and Quon, MJ, Vascular and metabolic actions of the green tea polyphenol epigallocatechin gallate, Current Medicinal Chemistry, 22, (1) pp. 59-69. ISSN 0929-8673 (2015) [Refereed Article]

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Copyright 2015 Bentham Science Publishers

Official URL: http://benthamscience.com/journals/current-medicin...

Abstract

Epidemiological studies demonstrate robust correlations between green tea consumption and reduced risk of type 2 diabetes and its cardiovascular complications. However, underlying molecular, cellular, and physiological mechanisms remain incompletely understood. Health promoting actions of green tea are often attributed to epigallocatechin gallate (EGCG), the most abundant polyphenol in green tea. Insulin resistance and endothelial dysfunction play key roles in the pathogenesis of type 2 diabetes and its cardiovascular complications. Metabolic insulin resistance results from impaired insulin-mediated glucose disposal in skeletal muscle and adipose tissue, and blunted insulin-mediated suppression of hepatic glucose output that is often associated with endothelial/vascular dysfunction. This endothelial dysfunction is itself caused, in part, by impaired insulin signaling in vascular endothelium resulting in reduced insulin-stimulated production of NO in arteries, and arterioles that regulate nutritive capillaries. In this review, we discuss the considerable body of literature supporting insulin-mimetic actions of EGCG that oppose endothelial dysfunction and ameliorate metabolic insulin resistance in skeletal muscle and liver. We conclude that EGCG is a promising therapeutic to combat cardiovascular complications associated with the metabolic diseases characterized by reciprocal relationships between insulin resistance and endothelial dysfunction that include obesity, metabolic syndrome and type 2 diabetes. There is a strong rationale for well-powered randomized placebo controlled intervention trials to be carried out in insulin resistant and diabetic populations.

Item Details

Item Type:Refereed Article
Keywords:EGCG, endothelial function, green tea, insulin action, insulin sensitivity, metabolism, muscle blood flow, type 2 diabetes
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Preventive Medicine
Author:Keske, MA (Dr Michelle Keske)
Author:Ng, HLH (Miss Huei Ng)
Author:Premilovac, D (Dr Dino Premilovac)
Author:Rattigan, S (Professor Stephen Rattigan)
ID Code:104777
Year Published:2015
Web of Science® Times Cited:27
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-11-19
Last Modified:2017-11-02
Downloads:0

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